Welcome to Scribd, the world's digital library. Read, publish, and share books and documents. See more
Standard view
Full view
of .
Look up keyword
Like this
0 of .
Results for:
No results containing your search query
P. 1
Kidney Diseases - VOLUME ONE - Chapter 18

Kidney Diseases - VOLUME ONE - Chapter 18

Ratings: (0)|Views: 91|Likes:
Published by Firoz Reza
Chapters are from VOL 1 of Atlas of Kidney Diseases. There are more 4 VOLUME. To get other VOLUME log on to http://www.kidneyatlas.org
Chapters are from VOL 1 of Atlas of Kidney Diseases. There are more 4 VOLUME. To get other VOLUME log on to http://www.kidneyatlas.org

More info:

Published by: Firoz Reza on Feb 24, 2009
Copyright:Attribution Non-commercial


Read on Scribd mobile: iPhone, iPad and Android.
download as PDF or read online from Scribd
See more
See less


Nutrition and Metabolismin Acute Renal Failure
dequate nutritional support is necessary to maintain proteinstores and to correct pre-existing or disease-related deficits inlean body mass. The objectives for nutritional support forpatients with acute renal failure (ARF) are not much different fromthose with other catabolic conditions. The principles of nutritional sup-port for ARF, however, differ from those for patients with chronic renalfailure (CRF), because diets or infusions that satisfy minimal require-ments in CRF are not necessarily sufficient for patients with ARF.In patients with ARF modern nutritional therapy must include atailored regimen designed to provide substrate requirements with var-ious degrees of stress and hypercatabolism. If nutrition is provided toa patient with ARF the composition of the dietary program must bespecifically designed because there are complex metabolic abnormali-ties that affect not only water, electrolyte, and acid-base-balance butalso carbohydrate, lipid, and protein and amino acid utilization.In patients with ARF the main determinants of nutrient require-ments (and outcome) are not renal dysfunction per se but the degree of hypercatabolism caused by the disease associated with ARF, the nutri-tional state, and the type and frequency of dialysis therapy. Pre-exist-ing or hospital-acquired malnutrition has been identified as an impor-tant contributor to the persisting high mortality in critically ill persons.Thus, with modern nutritional support requirements must be met forall nutrients necessary for preservation of lean body mass, immunocom-petence, and wound healing for a patient who has acquired ARF—inmay instances among other complications. At the same time the spe-cific metabolic alterations and demands in ARF and the impairedexcretory renal function must be respected to limit uremic toxicity.In this chapter the multiple metabolic alterations associated withARF are reviewed, methods for estimating nutrient requirements arediscussed and, current concepts for the type and composition of nutri-tional programs are summarized. This information is relevant fordesigning nutritional support in an individual patient with ARF.
Wilfred Druml 
Acute Renal Failure
Nutritional goals in patients with acute renal failure (ARF). Thegoals of nutritional intervention in ARF differ from those inpatients with chronic renal failure (CRF): One should not providea minimal intake of nutrients (to minimize uremic toxicity or toretard progression of renal failure, as recommended for CRF) butrather an optimal amount of nutrients should be provided for cor-rection and prevention of nutrient deficiencies and for stimulationof immunocompetence and wound healing in the mostly hypercata-bolic patients with ARF [1].
GoalsPreservation of lean body massStimulation of wound healing and reparatory functionsStimulation of immunocompetenceAcceleration of renal recovery (?)But not (in contrast to stable CRF)Minimization of uremic toxicity (perform hemodialysis and CRRT as required)Retardation of progression of renal failureThus, provision of optimal but not minimal amounts of substrates
Determined by
Renal dysfunction (acute uremic state)Underlying illnessThe acute disease state, such assystemic inflammatory responsesyndrome (SIRS)Associated complications (such asinfections)
Specific effects of renalreplacement therapyNonspecific effects of extracorporealcirculation (bioincompatibility)
Metabolic perturbations in acute renal failure (ARF). In mostinstances ARF is a complication of sepsis, trauma, or multipleorgan failure, so it is difficult to ascribe specific metabolic alter-ations to ARF. Metabolic derangements will be determined by theacute uremic state plus the underlying disease process or by com-plications such as severe infections and organ dysfunctions and,last but not least by the type and frequency of renal replacementtherapy [1, 2].Nevertheless, ARF does not affect only water, electrolyte, and acidbase metabolism: it induces a global change of the metabolic envi-ronment with specific alterations in protein and amino acid, carbo-hydrate, and lipid metabolism [2].
Energy metabolism in acute renal failure (ARF). In experimental ani-mals ARF decreases oxygen consumption even when hypothermiaand acidosis are corrected (uremic hypometabolism) [3]. In contrast,in the clinical setting oxygen consumption of patients with variousform of renal failure is remarkably little changed [4]. In subjectswith chronic renal failure (CRF), advanced uremia (UA), patientson regular hemodialysis therapy (HD) but also in patients with un-complicated ARF (ARFNS) resting energy expenditure (REE) wascomparable to that seen in controls (N). However, in patients withARF and sepsis (ARFS) REE is increased by approximately 20%.Thus, energy expenditure of patients with ARF is more deter-mined by the underlying disease than acute uremic state and takentogether these data indicate that when uremia is well-controlled byhemodialysis or hemofiltration there is little if any change in energymetabolism in ARF. In contrast to many other acute disease process-es ARF might rather decrease than increase REE because in multipleorgan dysfunction syndrome oxygen consumption was significantlyhigher in patients without impairment of renal function than inthose with ARF [5]. (
Schneeweiss [4]; with permission.)
Energy metabolism
Metabolic Alterations in Acute Renal Failure
Nutrition and Metabolism in Acute Renal Failure
Calculation of resting energy expenditure (REE) (Harris Benedict equation):Males: 66.47
age)Females: 655.1
age)The average REEis approximately 25 kcal/kg BW/dayStress factors to correct calculated energy requirement for hypermetabolism:Postoperative (no complications) 1.0Long bone fracture 1.15–1.30Cancer 1.10–1.30Peritonitis/sepsis 1.20–1.30Severe infection/polytrauma 1.20–1.40Burns (
approxim. REE
%burned body surface area) 1.20–2.00Corrected energy requirements (kcal/d)
stress factor
Estimation of energy requirements. Energy requirements of patients with acute renal failure (ARF) have been grossly over-estimated in the past and energy intakes of more than 50 kcal/kgof body weight (BW) per day (
, about 100% above restingenergy expenditure (REE) haven been advocated [6]. Adverseeffects of overfeeding have been extensively documented duringthe last decades, and it should be noted that energy intake mustnot exceed the actual energy consumption. Energy requirementscan be calculated with sufficient accuracy by standard formulassuch as the Harris Benedict equation. Calculated REE should bemultiplied with a stress factor to correct for hypermetabolicdisease; however, even in hypercatabolic conditions such as sepsisor multiple organ dysfunction syndrome, energy requirementsrarely exceed 1.3 times calculated REE [1].
Protein metabolism in acute renal failure (ARF): activation of protein catabolism. Protein synthesis and degradation rates inacutely uremic and sham-operated rats. The hallmark of metabol-ic alterations in ARF is activation of protein catabolism withexcessive release of amino acids from skeletal muscle and sus-tained negative nitrogen balance [7, 8]. Not only is protein break-down accelerated, but there also is defective muscle utilization of amino acids for protein synthesis. In muscle, the maximal rate oinsulin-stimulated protein synthesis is depressed by ARF and pro-tein degradation is increased, even in the presence of insulin [9].(
[8]; with permission.)
Protein metabolism

Activity (2)

You've already reviewed this. Edit your review.
1 thousand reads
1 hundred reads

You're Reading a Free Preview

/*********** DO NOT ALTER ANYTHING BELOW THIS LINE ! ************/ var s_code=s.t();if(s_code)document.write(s_code)//-->