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Kidney Diseases - VOLUME ONE - Chapter 09

Kidney Diseases - VOLUME ONE - Chapter 09



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Published by Firoz Reza
Chapters are from VOL 1 of Atlas of Kidney Diseases. There are more 4 VOLUME. To get other VOLUME log on to http://www.kidneyatlas.org
Chapters are from VOL 1 of Atlas of Kidney Diseases. There are more 4 VOLUME. To get other VOLUME log on to http://www.kidneyatlas.org

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Categories:Types, School Work
Published by: Firoz Reza on Feb 24, 2009
Copyright:Attribution Non-commercial


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Renal Histopathology, UrineCytology, and Cytopathologyof Acute Renal Failure
auses of acute renal failure can be divided into three categories:1) prerenal, due to inadequate perfusion; 2) postrenal, due toobstruction of outflow; and 3) intrinsic, due to injury to renalparenchyma. Among the latter, diseases of, or injury to, glomeruli,vessels, interstitium, or tubules may lead to a decrease in glomerularfiltration rate (GFR).Glomerular diseases that lead to acute renal failure are the proliferativeglomerulonephritides, including postinfectious and membranoprolif-erative glomerulonephritis secondary to glomerular deposition of immune complexes. If glomerular injury is severe enough to damagethe glomerular basement membrane, leakage of fibrin and otherplasma proteins stimulates formation of cellular extracapillary“crescents” composed of epithelial cells and monocytes andmacrophages. Crescents may form as a result of an inflammatoryreaction to immune complexes formed to nonglomerular antigens;antibody reaction to intrinsic glomerular antigens, as in anti–glomerularbasement membrane disease; and, in the absence of immunecomplexes, the pauci-immune processes, which include the smallvessel vasculitides, including Wegener’s granulomatosis and microscopicpolyarteritis. Immunohistologic examination and electron microscopyplay important roles in the diagnosis of these processes. Extensivecrescent formation is accompanied by rapidly progressive acute renalfailure. The urine sediment in these diseases often contains red bloodcells and red cell casts.Vascular diseases (involving veins, arteries, or arterioles and capillar-ies) can lead to hypoperfusion and acute renal failure. Venous thrombo-sis, most often due to trauma or a nephrotic state, and arterial throm-bosis due to trauma or vasculitis, cause parenchymal ischemia and
Lorraine C. Racusen Cynthia C. Nast 
Acute Renal Failure
(seeColor Plate)
Early postinfectious glomerulonephritis. Numerous polymorphonu-clear leukocytes in glomerular capillary loops contribute to thehypercellular appearance of the glomerulus. There is also a segmentalincrease in mesangial cells (hematoxylin and eosin, original magnifica-tion
400). This reactive inflammatory process occurs in responseto glomerular deposition of immune complexes, including the largesubepithelial “hump-like” deposits which are typical of post-infec-tious glomerulonephritis. The glomerulonephritis is usually self-limited and reversible, and especially with appropriate treatment of the underlying infection, long-term prognosis is excellent [1].
infarction. Small vessel vasculitides involve small arteries, arteri-oles, and glomerular capillaries, causing injury and necrosis in theglomerular tuft, which may result in crescent formation.Thrombotic microangiopathies result from endothelial injurydamage in small arteries and arterioles, producing thrombosis,obstruction to blood flow, and glomerular hypoperfusion. Urinesediment in these diseases often shows hematuria or cellular casts,reflecting ischemia.Interstitial inflammatory processes lead to acute renal failurevia compression of peritubular capillaries or injury to tubules.Causes of acute interstitial nephritis include infection, andimmune-mediated reactions. With infection, polymorphonu-clear leukocytes may be seen in tubules as well as in intersti-tium. Inflammatory infiltrates in hypersensitivity reactions,often due to drug exposure, feature eosinophils. Immuno-histologic studies may reveal the presence of immune complexes;immune complex deposition around tubules occurs as a primaryprocess or associated with immune glomerular injury. Tubulitisis seen when the inflammatory reaction extends into the tubu-lar epithelium. Epithelial cell injury is often produced by suchinflammatory processes. The urine sediment reveals whiteblood cells and white cell casts, which may include numerouspolymorphonuclear leukocytes or eosinophils.The most common cause of acute renal failure is injury totubule epithelium. Primary tubule cell injury typically resultsfrom ischemia, toxic injury, or both. Cell injury results in dis-ruption of the epithelium and its normal reabsorptive func-tions, and may lead to obstruction of tubule lumens. Cell exfo-liation often occurs, and intact cells and cell fragments anddebris can be seen in the urine sediment; these may be in theform of casts. Necrotic cells may be seen in situ along thetubule epithelium or in the tubule lumen, but often overt cellnecrosis is not prominent. Apoptosis of tubule cells is seenafter injury as well.
Glomerular Diseases
(seeColor Plate)
A large epithelial crescent fills Bowman’s space and compresses thecapillary loops in the glomerular tuft. This silver stain highlightsthe glomerular mesangium and the basement membrane of theglomerular capillaries (silver stain, original magnification
400).The patient presented with hematuria and acute renal failure.Immunostains were negative in this case, a finding consistent witha pauci-immune process. The differential diagnosis includes smallvessel vasculitis, and anti-neutrophil cytoplasmic antibody maybe positive. Crescentic glomerulonephritis may also occur withanti-glomerular basement membrane antibody disease, or as acomplication of immune complex glomerulonephritis [2].
Renal Histopathology, Urine Cytology, and Cytopathology of Acute Renal Failure
(seeColor Plate)
Urine sediment of a patient with acute renal failure revealing redblood cells and some red blood cell casts (original magnification
600). Biopsy in this case revealed crescentic glomerulonephritis.However, hematuria may be seen in any proliferative glomeru-lonephritis or with parenchymal infarcts. The “casts” assume thecylindrical shape of the renal tubules, and confirm an intrarenalsource of the blood in the urine. Fragmented or dysmorphic redblood cells may be seen when the red cells have traversed throughdamaged glomerular capillaries.
Vascular Diseases
(seeColor Plate)
An early thrombus is seen in a small renal artery in a patient withpatchy cortical infarction (original magnification
250). Thepatient presented with acute renal failure. The thrombosis may bedue to a hypercoaggulable state (
, disseminated intravascularcoaggulation) or endothelial injury (
, hemolytic uremic syn-drome). If the cortical necrosis is patchy, recovery of adequaterenal function may occur [3].
(seeColor Plate)
A parenchymal infarct in a patient with renal vein thrombosis (hema-toxylin and eosin, original magnification
200). A few survivingtubules and a rim of inflammatory cells are seen at the periphery of the infarct. Infarcts may also be seen with arterial thromboses, andwith severe injury to the microvasculature, as occurs in thromboticmicroangiopathies [3]. If the process is extensive, acute corticalnecrosis may occur, often leading to irreversible renal failure.

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