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70 Important Seqs of Biochemistry for 1st Year Mbbs Students by Dr Roomi

70 Important Seqs of Biochemistry for 1st Year Mbbs Students by Dr Roomi

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70 IMPORTANT SEQs OF BIOCHEMISTRY FOR 1
ST
YEAR MBBS STUDENTS BY DR ROOMI
Q.1.a): define pH. What is the influence of pH on the structure and function of  biological molecules? 0.5, 1.5B). Name the processes which help in the transport of substances across the cellmembrane. Enumerate four important factors that determine net diffusion of asubstance across the biological membrane. 1, 1.Q2. A. Write Henderson Hasselbalch equation.B. Give its applications. (1, 4)Q3: Explain briefly how volume of water is regulated in the body. (5)Q.4: a). what are G proteins? How are G proteins activated and inactivated? 2B). Define pH and buffer solution. Give four examples of body buffers along withthe site where they act the best? 2Q.5: a).What are intracellular events following the activation of Gq proteins? 2Q6. Patient was brought in OPD with the history of excessive urination for the last24 hours. On examination he was dehydrated. His urine was diluted and specificgravity was below normal. His renal profile was found to be normal.A. What is the most probable diagnosis?B. What would be the effect on extracellular osmolarity of this patient?C. How cells will respond to this change?1, 2, 1Q.7 : b). Define osmotic pressure. What is the importance of osmotic pressureexerted by plasma proteins? 2Q.8.a): Define isotonic, hypotonic, and hypertonic solutions. 1.5B). Enumerate body buffers. How do these help in buffering volatile acids. 2.5Q.9.a): enumerate the ways by which acid base balance of the body is maintained.2B). Enlist the processes which help in transport of the substances across the cellmembrane. 2
 
 Q.10: a). Define disaccharides. Give three examples. Write down their products of hydrolysis. 2B). Draw the structure of cholesterol. Give its three physiochemical properties andfunctions in the body. 2Q.11: a). A young lady presents to a clinic with complaints of alternating diarrheaand constipation. She complains of abdominal discomfort and bloating that isrelieved with her bowel movement. She states that her episodes are worse at timesof stress. She denies of any blood in her stool. Her physical examination is allwithin normal range. She has been prescribed cellulose containing dietarysupplement, which her doctor says will increase the bulk of stools. She wasdiagnosed as a case of irritable bowel syndrome (IBS).I). what
is the biochemical mechanism of this dietary supplement’s effect on the
intestine? 1Ii). what is the structure of cellulose? 0.5Iii). what is hemicellulose? 0.5Q.12: (a). Differentiate between homopolysaccharides and heteropolysaccharides.(1 marks)(b). Describe briefly the functions of glycosaminoglycans in our body. (3 marks)Q.13:b).What do you understand by omega- 3 fatty acids? What are the principal biological functions of prostacyclin and leukotriene B4? 2Q.14.a): define isotonic solution. Give normal value and importance of plasmacolloidal osmotic pressure. 1, 2, 1.Q.15. A): define disaccharides. Give one example. What is meant by lactoseintolerance? 1, 2, 1.Q.16. A): define homoplysaccharides. Name four of them with one major functionthey perform. 2B): classify phospholipids and write down their four important biologicalfunctions. 2Q.17: define with examples:A). Saturated fatty acids. 1B). Unsaturated fatty acids. 1
 
C). nutritionally essential fatty acids. 2Q.18. A): Give the chemistry of sucrose and lactose.1,1B): What is lactose intolerance? 2Q.19: Describe oxidation and reduction of monosaccharides along with examples.Describe important functions of hyaluronic acid in body? 1+1Q.20: what are glycosaminoglycans (GAGs)? Enumerate various classes of GAGs. 1, 3.Q.21: A female patient was brought to outdoor department with generalized edemawhich was of gradual onset. She belonged to a poor family having six children.The youngest one was 1 year of age and was being breastfed. On clinicalexamination she looked pale and malnourished. Her heart was normal with nohistory of blood pressure (hypertension). Her labs showed low plasma albuminlevels (proteins). Explain biochemical cause of edema in this patient. 5Q.22: classify amino acids on the basis of their side chains(R groups). What are
standar6d and non standard amino acids”? 3, 1.
 Q.23: Classify amino acids on the basis of their side chains (R groups). What arestandard and non standard amino acids? 3, 1.Q.24: what is the role of amino acid side chain (R group) in protein folding?Briefly describe the relationship of protein structure to its functions. Give at leastone example. 2Q.25: a). What is selenocsteine? Write down its significance. 1.5B). A young girl consulted nutritionist to discuss about vegetarian diet to looseweight. He advised her diet which contained sufficient amount of essential aminoacids along with carbohydrates, fat, proteins, vitamins and minerals. He alsoadvised that she must take six classes of water daily, so that she can keep up goodhealth.I). What do you understand by nutrition ally essential amino acids? 0.5Ii). Enlist essential amino acids for humans? 1.5Iii). Which of the essential amino acids contains sulphur in its structure? 0.25Iv). Which of the essential amino acids is purely ketogenic? 0.25

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