• Embed Doc
  • Copy Link
  • Readcast
  • Collections
  • CommentGo Back
Download
 
Disorders of iron metabolism and hem synthesis
 
•Iron deficiency and iron deficiency anemia•The anemia of chronic disorders•Sideroblastic anemias•Methemoglobinemia and other disorders with cyanosis•Hemochromatosis•Porphyria
 
Iron metabolism
•Most body iron is present in haemoglobin in circulating redcells•The macrophages of the reticuloendotelial system store ironreleased from haemoglobin as ferritin and haemosiderin•They release iron to plasma, where it attaches to transferrinwhich takes it to tissues with transferrin receptors – especiallythe bone marrow – where the iron is incorporated by erythroidcells into haemoglobin•There is a small loss of iron each day in urine, faeces, skin andnails and in menstruating females as blood (1-2 mg daily) isreplaced by iron absorbed from the diet.
 
Stages in the development of iron deficiency
•Prelatent
 – reduction in iron stores without reduced serum iron levels•Hb (N), MCV (N), iron absorption (
↑
), transferin saturation (N),serum ferritin (
↓
), marrow iron (
↓
)
•Latent
 – iron stores are exhausted, but the blood haemoglobin level remainsnormal•Hb (N), MCV (N), TIBC (
↑
), serum ferritin (
↓
), transferinsaturation (
↓
), marrow iron (absent)
•Iron deficiency anemia
 –  blood haemoglobin concentration falls below the lower limit of normal•Hb (
↓
), MCV (
↓
), TIBC (
↑
), serum ferritin (
↓
), transferin saturation(
↓
), marrow iron (absent)
of 00

Leave a Comment

You must be to leave a comment.
Submit
Characters: ...
You must be to leave a comment.
Submit
Characters: ...