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1© The Author 2009. Published by Oxford University Press. All rights reserved.For permissions, please e-mail: journals.permissions@oxfordjournals.org
A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis
Authors
Adriano Chiò
1+
, Jennifer C Schymick 
2,3,+
, Gabriella Restagno
4,+
, Sonja W. Scholz
5,6
, FedericaLombardo
4
,
 
Shiao-Lin Lai
5,7
, Gabriele Mora
8
, Hon-Chung Fung
2,7
, Angela Britton
5
, SampathArepalli
5
, J. Raphael Gibbs
6,9
, Michael Nalls
5
, Stephen Berger 
2
, Lydia Coulter Kwee
10,11
, EugeneZ. Oddone
11,12
, Jinhui Ding
9
, Cynthia Crews
2
, Ian Rafferty
2
, Nicole Washecka
2
, DenaHernandez
5,6
, Luigi Ferrucci
13
, Stefania Bandinelli
14
, Jack Guralnik 
15
,
Fabio Macciardi
16
,Federica Torri
16
, Sara Lupoli
17
, Stephen J Chanock 
18
, Gilles Thomas
18
, David J Hunter 
18,19
,Christian Gieger 
20,21
, H.-Erich Wichmann
20,21
, Andrea Calvo
1
, Roberto Mutani
1
,
 
StefaniaBattistini
22
, Fabio Giannini
22
, Claudia Caponnetto
23
, Giovanni Luigi Mancardi
23
, Vincenzo LaBella
24
, Francesca Valentino
24
, Maria Rosaria Monsurrò
25
, Gioacchino Tedeschi
25
, KalliopiMarinou
8
, Mario Sabatelli
26
, Amelia Conte
26
, Jessica Mandrioli
27
, Patrizia Sola
27
, FabrizioSalvi
28
, Ilaria Bartolomei
28
, Gabriele Siciliano
29
, Cecilia Carlesi
29
, Richard W. Orrell
30
, KevinTalbot
3
, Zachary Simmons
31
, James Connor 
32
, Erik P. Pioro
33
, Travis Dunkley
34
, Dietrich A.Stephan
34
, Dalia Kasperaviciute
35
,
 
Elizabeth M. Fisher 
35
, Sibylle Jabonka
36
, Michael Sendtner 
36
,Marcus Beck 
36
, Lucie Bruijn
37
, Jeffrey Rothstein
38
, Silke Schmidt
10,11
, Andrew Singleton
5
, JohnHardy
2,6
, Bryan J. Traynor 
2,38,*
 
Affiliations
1
Department of Neuroscience, University of Turin, Turin, Italy
2
Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD, USA
3
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK 
4
Molecular Genetics Unit, Department of Clinical Pathology, A.S.O. O.I.R.M.-S.Anna, Turin,Italy
5
Molecular Genetics Unit, Laboratory of Neurogenetics, National Institute on Aging, NIH,Bethesda, MD, USA
HMG Advance Access published February 4, 2009
 
2
6
Department of Molecular Neuroscience and Reta Lila Weston Institute of Neurological Studies,Institute of Neurology, Queen Square, London, UK 
7
Department of Neurology, Chang Gung Memorial Hospital and College of Medicine, Taiwan.
8
Salvatore Maugeri Foundation, Lissone, Italy
9
Computational Biology Core, Laboratory of Neurogenetics, National Institute on Aging, NIH,Bethesda, MD, USA
10
Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, USA
11
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
12
Epidemiology Research and Information Center, Durham VAMC, North Carolina, USA
13
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging,Baltimore, Maryland, USA
14
Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy
15
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging,Bethesda, Maryland, USA
16
Department of Science and Biomedical Technology, University of Milan, Italy
17
INSPE, San Raffaele Scientific Institute, Milan
18
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD
19
Department of Epidemiology, Harvard School of Public Health, Boston, MA
20
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg/Munich, Germany
21
Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
22
Department of Neuroscience, Neurology Section, University of Siena, Siena, Italy
23
Department of Neuroscience, Ophthalmology and Genetics, University of Genoa, Italy
24
Department of Clinical Neurosciences, University of Palermo, Italy
25
Department of Neurological Sciences, Second University of Naples, Italy
 
3
26
 Neurological Institute, Catholic University and I.CO.M.M. Association for ALS Reseach,Rome, Italy
27
Department of Neuroscience, S. Agostino- Estense Hospital, and University of Modena, Italy
28
Center for Diagnosis and Cure of Rare Diseases, Department of Neurology, Bellaria Hospital,Bologna, Italy
29
Department of Neuroscience, University of Pisa, Italy
30
University Department of Clinical Neurosciences, Institute of Neurology, University CollegeLondon, London
31
Department of Neurology, Penn State College of Medicine, Hershey, PA, USA
32
Department of Neurosurgery, Penn State College of Medicine, Hershey, PA, USA
33
Department of Neurology, Cleveland Clinic, Cleveland, OH
34
 Neurogenomics Division, Translational Genomics Institute (TGEN), Phoenix, AZ
35
Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square,London, UK 
36
Institute of Clinical Neurobiology, University of Wuerzburg, Wuerzburg, Germany.
37
The ALS Association, Palm Harbor, FL, USA
38
Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
+
These authors contributed equally to this work.*Corresponding author Bryan J. Traynor, National Institutes of Health, Building 35, Room 1A/1000, 35 Convent Drive,Bethesda, MD 20892-3720
 
Email:
traynorb@mail.nih.gov;
Phone:
(301) 451 7606;
Fax:
(301) 451-7295
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