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9.0 Pentose Phosphate Pathway

The Pentose Phosphate Pathway produces reducing power in the form of NADPH that the cell can
use to fuel biosynthetic reactions and produce a number of other sugars. The three, four, five, six,
and seven carbon sugars produced by the pentose phosphate pathway can enter a number of
biosynthetic or oxidative pathways. Glycolytic intermediates such as glyceraldehyde 3-phosphate
can be used to produce ATP while other sugars such as ribose 5-phosphate can be used to synthesize
nucleotides. Click the enzyme or substrate labels for more information.

9.10 Glucose 6-Phosphate Dehydrogenase
Glucose 6-Phosphate Dehydrogenase converts glucose 6-phosphate to 6-phosphogluconolactone
while reducing NADP+ to NADPH.
9.20 6-Phosphoglucolactonase
6-Phosphoglucolatonase hydrates 6-phosphogluconolactone, converting it to 6-phosphogluconate.
9.30 6-Phosphogluconate Dehydrogenase
6-Phosphogluconate Dehydrogenase converts 6-phosphogluconate to ribulose 5-phosphate and CO2
while reducing NADP+ to NADPH.
9.40 Ribose 5-Phosphate Isomerase
Ribose 5-Phosphate Isomerase reversibly converts ribulose 5-phosphate to ribose 5-phosphate.
9.50 Phosphopentose Epimerase
Phosphopentose Epimerase reversibly converts ribulose 5-phosphate to xylulose 5-phosphate.
9.60 Transketolase

Transketolase reversibly converts xylulose 5-phosphate and ribose 5-phosphate to sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate. Transketolase can also reversibly convert erythrose 4-phosphate and xylulose 5-phosphate to fructose 6-phosphate and glyceraldehyde 3-phosphate.

9.70 Transaldolase
Transaldolase reversibly converts glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate to
fructose 6-phosphate and erythrose 4-phosphate
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