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Veterinary World, Vol.1, No.4, April 2008
Introduction
The anthelminthic therapy (with doramectin andfenbendazole) gastrointestinal infection in dairy ani-mals of central zone of vidarbha region(Maharashtra) was studied during the period fromJuly 2002 to June 2003 at Nagpur. The prevelanceof major helminth parasites was observed includesnematode.
Trematodes 
and cystode like
para- amphistomes, Toxocara, Moneizia,strongyl-oides,Haemonchrus , Fasciola, Schistosoma ,Trichuris,Oesophagostonum 
and
Trichostronglyous 
species.The helminth infection result in greatecomomic losses to livestock industry due todeterioration of health and reduced production ofanimals (Mahesh kumar,2002).Naturally infecteddairy animal showed the clinical symptoms such asrough body coat, ematiation ,dirrheoa and weaknessetc. The dairy animals naturally infected with mixedgastrointestinal helminth were used to assess therelative efficacy of anthelmintics viz.Doramectin andfenbendazole.
Material and Method
Doramectin (Pfizer India Ltd. Bombay) andfenbedazole (Intervet India Pvt. Ltd.) were evaluated
Efficacy of Doramectin and Fendendazole againstnaturally infected dairy animals with parasites atcentral zone of vidarbha region 0f Maharashtra State
A.S Gadre, D.K. Maske, C.G. Panchbhai, T.R. Gawande, S.W. Kolte, A.R. SirothiaDepartment of Parasitology,Nagpur Veterinary College, MAFSU, Nagpur -06
Abstract
Comparative efficacy of doramectin and fenbendazole was studied against naturally infected dairy animalswith helminth parasites showing clinical symptoms such as rough body coat, emaciation, diarrhoea andweakness etc. Based on the number of days taken for clinico-parasitological cure and the mean reductionEPG, doramectin was found to be superior to fenbendazole.
Keywords
: Doramectin, Fenbendazole, Helminth, natural infection, Vidarbha region,
(Mean eggs values before treatment)-(Mean eggs values after treatment)(Mean eggs values before treatment)x 100
for their efficacy in naturally infected dairy animals.The dose of all drugs and their mode of admini-strationis given in table.
Group-I – Doramectin @ 1 ml/ 50 kg s/cGroup-II – Fenbendazole @ 7.5 mg/ kg orallyGrpoup–III – was kept as the infected, untreated anduninfected untreated.
In this therapy 30 parasitic infected animals fromyavatmal district were used and divided into threegroups. To assess the efficacy of drugs the faecalsample of all cattle were examined with respect toreduction of eggs. Animal under study were dividedinto three groups, each group consisting of 10 animals.Out of these two groups was given anthelminthic atthe doses given below.To assess the efficacy of drugs , the faecalsample of all animals were examined daily withrespect to reduction of eggs. The efficacy wascalculated as fallows:
Result and Discussion
Doramectin was given subcutaneously at thedose rate of 1 ml/ 50 kg body weight per animal once
=
GroupDrugEPG /gram doses(mean) on daysPercent reduction of EPG on days(Efficacy)0 day7 day 14 day21st day7th day 14th day21st day
IDoramectin514080————98.68100100IIFenbendazole5250610190——89.5796.92100IIIInfected5350531053605450untreated
Table-1. Efficacy of Dormactin and fenbendazole on different groups.
RESEARCH
Veterinary World, Vol.1(4): 101-102101
Efficacy of treatment
of 00

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