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A short primer on
Exfoliative respiratory cytology
September 2007
 
Acquisition of specimens
•Sputum•BAL / Bronchial wash•Bronchial brush•Pleural fluid•Needle biopsy
 –Transbronchial –Transesophogeal –Transaortic
•Transthoracic FNA
 
Sputum
•Accuracy
 –Patient is spontaneously producing sputum –Vigorous sampling (3-5 early morning specimens) –Preservation techniques –Location and size of tumor 
•Central (SCLC, SCC)
 –Sensitivity:
•Sens 0.66, Spec 0.99
(average 16 studies)
•Prebronchoscopy
 –suspected Lung Ca: sens 0.10-0.74 (8 studies)
•Central sens 0.71, Peripheral sens 0.49
(17 studies)
of 00

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