Scribd Logo
Upload

Welcome to Scribd!

  • Evan's Syndrome: Autoimmune Disease Attacking Red Blood Cells and Platelets

    Uploaded by

    Kimberlie Dela Merced Tomas
    5 views4 pages
    Evans syndrome is an autoimmune disease where antibodies attack red blood cells and platelets, causing hemolytic anemia and thrombocytopenia. It has no known cause but involves autoantibodies targeting blood cells and abnormal T cell levels. Patients may initially present with symptoms of anemia or low platelet count alone or together, and treatment involves corticosteroids, IVIG, or immunosuppressive drugs if initial treatment is ineffective.

    Original Description:

    Original Title

    Power Ward 5

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    PPTX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Evans syndrome is an autoimmune disease where antibodies attack red blood cells and platelets, causing hemolytic anemia and thrombocytopenia. It has no known cause but involves autoantibodies targeting blood cells and abnormal T cell levels. Patients may initially present with symptoms of anemia or low platelet count alone or together, and treatment involves corticosteroids, IVIG, or immunosuppressive drugs if initial treatment is ineffective.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    5 views4 pages

    Evan's Syndrome: Autoimmune Disease Attacking Red Blood Cells and Platelets

    Uploaded by

    Kimberlie Dela Merced Tomas
    Evans syndrome is an autoimmune disease where antibodies attack red blood cells and platelets, causing hemolytic anemia and thrombocytopenia. It has no known cause but involves autoantibodies targeting blood cells and abnormal T cell levels. Patients may initially present with symptoms of anemia or low platelet count alone or together, and treatment involves corticosteroids, IVIG, or immunosuppressive drugs if initial treatment is ineffective.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 4

    Evans syndromE

    is an autoimmune disease in which an individual's antibodies attack their own red blood cells and platelets .Both of these events may occur simultaneously or one follow on from the other. Its overall pathology resembles a combination of autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura.

    PATHOPHYSIOLOGY
    The etiology of Evans syndrome is unknown. Norcross reacting autoantibodies are directed against antigens specific to red cells, platelets, or neutrophils. Wang et al demonstrated decreased levels of serum immunoglobulin (Ig) G, IgM, and IgA in these patients. The cytopenias that occur with Evans syndrome may be related to Tcell abnormalities because decreased Thelper cells and increased T-suppressor cells were noted in these patients.

    CLINICAL MANIFESTATION
    Patients may present with AIHA or ITP either separately. Thrombocytopenia; petichiae,bruising, mucocutaneous bleeding Examination may reveal lymphadenopathy, hepatomegaly and/or splenomegaly

    TREATMENT First Line Therapy; corticosteroids


    and/or intravenous immunoglobulin.

    Second Line Therapy; include immunosuppressive drugs, especially cyclosporine or mycophenolate mofetil; vincristine; danazol or a combination of these agents.

    You might also like