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Colon Adenocarcinoma

Colon Adenocarcinoma

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Published by Buyung Punya Suster

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Published by: Buyung Punya Suster on Mar 28, 2013
Copyright:Attribution Non-commercial


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What is colon adenocarcinoma?
Colon adenocarcinoma is the most common type of gastrointestinal cancer, with about 140,000cases each year in the United States, according of the National Cancer Institute. This type of cancer begins in the cells of glandular structures in the inner layer of the colon and spreads
rst into the wall of the colon and potentially into the lymphatic system and other organs. Colonadenocarcinoma can be treated, with 50 percent of patients surviving for at least ve years.
Early-stage colon cancers have survival rates of 70 to 80 percent.
Who is most likely to have colon adenocarcinoma?
Colon cancer stems from colon polyps that turn cancerous,and individuals who develop polyps are at the highest risk of colon cancer. For this reason, individuals with a family historyof 
adenomatous polyposis
Gardner’s syndrome
 –bothmarked by the growth of multiple colon and rectal polyps–areat high risk. Individuals age 50 or older who are not screenedregularly for polyps are at higher risk, as well, since polypsgrow in 30 percent of individuals past the age of 50. Coloncancer also is associated with a diet high in fat and beef and
low in ber. Other risk factors include a personal history of previous cancer or inammatory bowel disease.
What characterizes colon adenocarcinoma?
Colon adenocarcinoma progresses slowly and may not present symptoms
for up to ve years. As the cancer grows, symptoms become more likely
and can include rectal bleeding, fatigue, shortness of breath, angina,changes in bowel habits, abdominal discomfort, anemia, or bowel obstruction.
What tests can help identify colon adenocarcinoma?
Because most colon adenocarcinomas do not presentsymptoms, most are found through regular physical
examinations. About 5 to 10 percent of colon cancers are
initially discovered during a
digital rectal exam (DRE),
in which
a primary care physician inserts a lubricated, gloved nger intothe patient’s rectum. A
blood test 
also can show the possibilityof colon cancer, as can various tests that examine the colon.These tests include
colonoscopy, exible sigmoidoscopy,
double-contrast barium enema.
How does a pathologist diagnose colon adenocarcinoma?
Once the possibility of colon cancer is found, each polyp is removed through colonoscopyor exible sigmoidoscopy.
In some cases, when the tumor is advanced, the polyps may beremoved as part of surgery.In any case, it is the pathologist who closely examines the polyp’scells–called a
biopsy sample
 –under a laboratory microscope to determine the
specic diagnosis.
(continued on next page)
Colon Cancer 
Colon Adenocarcinoma
Copyright © 2011.
College of American
Pathologists. For use andreproduction by patients
and CAP members only.
The sectionof the large intestineleading to the rectum.
 A type of cancerous,
or malignant, tumor originating in aglandular (tubular)structure.
 A benign
tumor found in thecolon. Polyps canbecome cancerous if undetected or ignored.
Cancerousand capable of spreading.
Invasive, Infltrating:
Capable of spreadingto other parts of thebody.
physician whoexamines tissues and
uids to diagnose
disease in order to assist in makingtreatment decisions.
Relatingto lymph glands (lymphnodes).
Colonadenocarcinomaprogresses slowlyand may not showsymptoms for up to
ve years.
Normal colon tissue.

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