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2001-3Medical pre pg entrance made easyPage 1 of 15

MAHE 2000MAHE PG ENTRANCE 2000ANSWERS (MANIPAL)

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This paper was contributed by Dr. PrashantGupta , MD(patho),Ex- B.S.Medical College,Bankura, West Bengal and Dr. ShraddhaAgarwal, Ex- Mysore Medical College, Mysore

Anatomy

1. Regarding trigeminal nerve true isa. Mesencephalic nuclei is multipolar, b.Sends proprioceptive fibres tomesencephalic nerve, c. Medially it isrelated to middle meningeal artery, d.Receives innervation from lateral horn of spinal cord.Ans: (b)2. Transverse vaginal sulcus correspondstoa. Junction of urethra and bladder, b.Junction of cervix and vagina, c. Lower limit of rectum, d. Upper limit of bladder.Ans: (a)3. True about pituitary gland isa. Adenohypophysis develops fromneuroectoderm, b. Contralataralhomonymous hemianopia occurs when pituitary tumor causes pressure over opticchiasma, c. Cord like arrangement in parstuberalis which produces gonadotropins,d. ADH and oxytocin produced in posterior pirtutary.Ans: (a)4. Which of the following aboutepithelium is true,a. Zona occludens is at basal portion; b.Capillaries go through the gap junctions,c. Basement membrane is formed by type4 collagen, d. In zona adherence actinfilaments connect adjacent cells throughmicrotubules.Ans: (c)5. About prostate true isa. Urethra penetrates apex, b. Centralzone is more prone for carcinoma than peripheral, c. Columella semilunarisopens into prostatic utricle, d. Posterior lobe separated by rectovesical pouch.Ans: (c)6. Which of the following types of collagen fiber is characteristic of hyalinecartilagea. Type I, b. Type II, c. Type III, d. TypeIV.Ans: (b)7. Lacrimal gland is supplied bya. Otic ganglion, b. Celiac ganglion, c.Trigeminal ganglion, d. Sympatheticchain ganglion.Ans: (a)

Physiology

1. Spermatogonia matures intospermatozoa ina. 40 days, b. 72 days, c. 96 days, d. 120days.Ans: (b)2. Synaptic transmission in auto nomicganglia is due toa. Cholinergic, b. Nicotinic, c. Muscarine,d. DopaminergicAns: (b)3. Amount of volume of air in lung after normal expiration isa. 2200ml, b. 4900ml, c. 1000ml, d.2700ml.Ans: (a)

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2001-3Medical pre pg entrance made easyPage 2 of 15

4. After moderate exercise, followingchanges occur in blood flow:a. Increase in heart rate, b. Increase inmuscle blood flow, c. Decrease in peripheral resistance, d. All of the above.Ans: (c)5. Which of the following forms blood brain Barrier a. Astrocytes, b. Microcytes, c.Oligodendrocytes, d. Endothelial cells.Ans: (d)6. Core body temperature is closest toa. Oral temperature, b. rectal, c. Surface,d. Axillary.Ans: (b)7. When Spinal cord is secured at thelevel of brainstem, the effect onrespiration will bea. Caeses, b. Normal, c. Irregular, d.ApneicAns: (d)8. Fetal oxygenation depends on allexcepta. HbF, b. Blood flow through placenta, c.Fetal respiration, d. Fetal heart rate.Ans: (c)9. In normal person, blood is preventedfrom clotting by all excepta. Plasminogen, b. Normal blood flow, c.natural anti clotting factor, d. Smoothendothelial cells.Ans: (a)10. Insulin like growth factor issynthesized ina. Placenta, b. Liver, c. islet of Langerhans, d. PitutaryAns: (b)11. Atrial natriuretic factor acts by:a. Membrane bound Guanyl cyclase, b.cytosolic Guanyl cyclase, c. solubleCGMP, d. Lipooxygenase.Ans: (a)12. Transmitter at neuromuscular functionsa. Nicotine, b. Atropine, c. Acetylcholine,d. NoradrenalineAns: (c)13. There is increase in secretion throughanterior pituitary bya. Hyperosmolarity of plasma, b.Somatostatin, c. Somatomedin, d.Suckling of breastAns: (b)14. Frontal lobe lesion causes are excepta. Acalculia, b. Emotional alteration, c.Personality changes, d. B+CAns: (a)15. EEG with eyes open, mind wanderingshowsa. Alpha waves, b. beta waves, c. Deltawaves, d. Theta wavesAns: (a)

Biochemistry

1. Which of the enzyme deficiency iscorrectly paireda. Farbers – Alpha galactosidase, b.Gauchers – Beta glucosidase, c. Niemann-picks – Beta galactosidase, d.Fabry’s disease – sphingomyelinase.Ans: (b)2. Glucose on anaerobic glycolysis isconverted toa. 2 lactate + NADPH + 2ATP, b. 2 pyruvate + 2 ATP + 2NADPH, c. 2 pyruvate + 2 lactate, d. 2 lactate + 2 ATPAns: (a)3. For initiation of protein synthesis in prokaryotes all are required excepta. Initiation factor, b. t-RNA, c. GTP, b.40s Ribosome.Ans: (d)

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2001-3Medical pre pg entrance made easyPage 3 of 15

4. Regarding oxidative phosphorylationall are true except: -a. Accept free O

, b. Protons facilitate it,c. Takes place in matrix of mitochondria,d. Inhibited by oligomycinAns: (b)5. Polymerase chain reaction is used for a. Amplification of human DNA, b.detecting RNA, c. Detecting DNA, d. To break sDNA to ssDNA.Ans: (a)6. Peptide bond true isa. Cleaved by denaturation of protein, b.Ionizes at normal pH, c. Stable at strong pH (acidic), d. Primary structuredetermines biologic activation andconfirmations.Ans: (d)Manipal A I P P G Paper 20007. Gene therapy isa. Inserting normal gene in place of abnormal ones, b. development of better genes for future generations, c. Removingthe abnormal gene only, d. All of theabove.Ans: (a)8. Which is true about porphyriaa. Read poisoning – ferrachelataseinhibition, b. Protoporhyrin oxidase is acytosolic enzyme, c. ALA synthaserequires TPP, d. Variegate porphyria – uroporphyin synthase I.Ans: (c)9. Risk factors for coronary artery diseaseare all excepta. Increase VLDL, b. Increase HDL, c.Increase LDL, d. All of the above.Ans: (b)

Pharmacology

1. Which of the following can be givenwith OCPa. Mebendazole, b. Amoxycillin, c.Phenytoin, d. RifampinAns: (a)2. Mode of action of vigabatrin isa. Inhibitor of GABA transaminaseincreasing GABA conc, b. Suppress Na

current channels, c. Inhibit T type Ca

channel, d. NoneAns: (a)3. Mode of action of baclofen isa. Act as GABA receptor agonist throhyperpolarising neurons by increasing k

conductance and altering ca

flux

, b.Depolarise muscle by opening Na

channel, c. Both, d. NoneAns: (a)4. Moricizine used as antiarrhythmiccauses: -a. Prolongation of action potential, b.Decrease action potential, c. No change inaction potential, d. None of the above.Ans: (a)5. All of the following can be usedagainst chloroquine resistant malariaexcepta. Mefloquine, b. Quinine, c. Primaquine,d. Halofantrine.Ans: (c)6. Ethanol elimination is aa. Linear elimination, b. Dose dependent,c. Saturation type, d. Fixed eliminationAns: (d)7. Prodrug used in prostatic carcinomawith antiandrogenic action isa. Cyproterone, b. Clomiphene, c.Danazol, d. TamoxifenAns: (a)