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Learning Objectives:
- Differentiate between exocrine and endocrine glands.
- Describe the structure of the thyroid gland.
- Explain how thyroxine is produced, regulated and state its
functions.
- Differentiate the symptoms of hypothyroidism and
hyperthyroidism.
• Overview: The Body’s Long-Distance Regulators
• An animal hormone
– Is a chemical signal that is secreted into the circulatory
system and communicates regulatory messages within
the body
PANCREAS
TESTES
OVARIES
• The nervous system
– Conveys high-speed electrical signals along specialized
cells called neurons
• Negative feedback
– Regulates many hormonal pathways involved in
homeostasis
– High concentration of a hormone or some other
substance inhibits further secretion.
• Four major classes of molecules function as hormones in
vertebrates
– Reception
– Signal transduction
– Response
Endocrine Disorders
• Hyposecretion
– abnormally reduced output of hormones
• Hypersecretion
– abnormally increased output of hormones
The thyroid gland
• Located in the neck. Consists of two lobes located on the
ventral surface of the trachea
• Secretes thyroxine, which contains iodine.
• The secretory cells form follicles, in which inactive precursor
of the hormone, thyroglobulin, is stored before being
converted into thyroxine and released into bloodstream.
• Numerous capillaries lie between the follicles, their thin walls
in close contact with the thyroid cells.
• The hypothalamus and anterior pituitary
– Control the secretion of thyroid hormones through two
negative feedback loops
Hypothalamus
Anterior
pituitary
TSH
Thyroid
T3 + T4
How thyroxine is produced?
- Thyroid cells takes up tyrosine and iodide ions from the
blood by active transport.
- Once inside the thyroid cells, iodide is oxidized into iodine.
- Iodine is incorporated into thyroglobulin.
- Thyroglobulin is transferred by exocytosis into the follicle and
stored.
- When the body needs thyroxine, thyroglobulin is taken up by
endocytosis into the thyroid cells and is converted into
thyroxine and secreted into the bloodstream when instructed
by the TSH (Thyroid Stimulating Hormone). Thyroid cells
contains a protease which removes the conjugated protein,
thus allowing the free hormone to be released.
Functions of thyroxine
- Thyroxine controls the basal metabolic rate (BMR), and is
therefore important in growth.
- If undersecretion – hypothyrodism.
- Causes: damaged thyroid gland, iodine deficiency
- If occurs during teenagers – patient is physically and
mentally retarded – called cretinism
- If occurs in adult – effect is not serious because the growth
has completed – called myxoedema. Symptoms are
decreased metabolic rate, increased subcutaneous fat, skin
is coarse, physical and mental sluggishness.
- If oversecretion called hyperthyroidism.
- Causes: thyroid tumour
- Symptoms are exophthalmos (bulging of the eye anteriorly),
goitre, increased metabolic rate, thin (loss of body fat), heart
rate increased, physical and mental restlessness.
Hormone
molecule
VIA
BLOOD
Signal receptor
TARGET
CELL
Signal
transduction
pathway
Cytoplasmic OR
response
Hormone
molecule
VIA
BLOOD
TARGET
CELL
Signal
receptor
Signal DNA
transduction
and response
mRNA
NUCLEUS
Hypothalamus
Pineal gland
Pituitary gland
Thyroid gland
Parathyroid glands
Adrenal glands
Pancreas
Ovary
(female)
Testis
(male)
• Major human endocrine glands and some of their
hormones
Relation Between the Hypothalamus and Pituitary Gland
Hypothalamus
Neurosecretory
cells of the Axon
hypothalamus
Posterior
pituitary
Anterior
pituitary
HORMONE FSH and LH TSH ACTH Prolactin MSH Endorphin Growth hormone
TARGET Testes or Thyroid Adrenal Mammary Melanocytes Pain receptors Liver Bones
ovaries cortex glands in the brain
• The anterior pituitary
– Is a true-endocrine gland
– Prolactin
– Melanocyte-stimulating hormone (MSH)
• Prolactin stimulates lactation in mammals
– But has diverse effects in different vertebrates