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T11.Grupele de Singe

T11.Grupele de Singe

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Published by Ion Gorbuli

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Published by: Ion Gorbuli on Apr 18, 2013
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05/27/2015

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ii4'lstоriсul dеzvоltirii сuno;tin{еlоr еsprеgrupеlеdеsflngеiRhfасtor.Dеtеrminarеagrupеide sflngе9iа Rh fасtorului.Transfu zia desf,nge.
Grupa dеs6ngе еstе o сombinarеsеInnеmunologiсе9igеnеtiсеnormale,dеtеrminatеprinеrеditatе9ireprez1nt6o сalitatе bio1ogiс6individual6.in 1900 baсtеriologul din Viеna Landqtеinеrqiсolaboratorii auintrodus сonсеptul dеgrupsangvinqiauidеntifiсat primеlе3grupе.Cеvamai tArziu-in anul 1902stwili,1907Janskiqiin 1910 Мoss indеpеndеntunul dе altul au idеntifiсatgrupaapatra.Dunghеrn9iGhirqfeld au desсopеrit inеritroсitеlе omului2aglutinogеni,marсAndu-ipriAqiB. inp|azm6,е afl6 rеspесtiv2 aglutininiсl,qiB.MaitАrziua fost idеntifiсatqiaglutinogеnulo,сarееstе un antigеnslab9iеlipsitdе important6raсtiсй.Aglutinogеnii suntpolipeptiziсusеdiulinstroma еritroоitеlor,dar maipotfig6sitеn lеuсoсitе, spеrm6,salivй,suсgastriс.Еi sunt tеrmostabili,suportй tеmperaturй 1000timp 24 orе$i-srеzistenli la usсarе.AglutinogеnulpоateaУea сitеva variеtйtiArl А2indеpendеnlideaglunabilitatе(fo4adе aglutinarе).nprezentaufostidentifiсali сirсa7500dе antigеni еritroсitariimpфili in9sistemе, nsё importan}6praсtiсio aunumai AgiB.Aglutininilес9iBg6sеsсn fraс}iagamaa globulinеlorplasmеiqi-smaiputinitеrmostabile, suportindtempеratura sub 600. ЕlеimpartinNaturalе(с.,сareomul sе nagtе)9iImunе(сarеaparpe parсursulontogеnеzеi, sprе еxеmplu- aglutininеanti-rezus). Мai dеosеbimaglutininе,,larесе,',сare .qi manifest6 еaс}iaеaglutinarе atеmpеrafura40-+160qiaglutininе,lacald'' aсtivitatеamaximalйatеmperatura+з70 +420.n afar6de aсеasta intAlnesс aglutininесomplеtе,сarеag1utineaz6ritroсitеlеin
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mеdiu salin9iсoloidal, preсumqiinсomplеtе,iindaсtivеnuaminmеdiuсo1оidal.Еritroсitеlеmanеpotсonlinеambiiaglutinogеni,nulsingursauniсiunul,tota$aqiinplasmйpotfi intAlnitеmbеlеaglutininе'unasingur5auniсiuna. indеpеndеn!6е aсеastanprеzеntprintrеioсuitorii globultiiсonformsistеmuluiABo, potfi intAlnitе4grupеsangvinе:o(I)o,B;A(II)p;B(III)g;АB(Iv)o.Dесi inmеdiсinapraсtiсйtermеnul,,GrupasAngе,,сa regulй,rеflесtйombinarеantigеnilorеritroсitarisistеmuluiABoqiaantiсorpilorirеspесtivinsеrul sangvin.iGrupеlе des6ngеsе mogtеnеsсrineriditatесonformlеgilorclasiсеalеgеnеtiсii,йm6n6ndtabilеtotparсursuliеfii.Frесvеntadupйgrup:1-З3,5Yo;
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IV-8,1%Rеaсliadе aglutinarее idеntiсЁсеlеidе imunitatе,aglutinоgеniiiindantigеni,araglutininеlе_antiсorpi.Reaсliaaglutinarearе loсatunсi,с6ndaglutinogеniiеritroсitеlordonatoruluintAlnеsоnplasmaprimitoruluiaglutininеleеspесtive Asе ntAlnеqteu0, B_"'P,rеgulauiottеnbегg).Dесi,сonformaсеstеirеgulisuntaglutinatеnumaiеritroсitеlеdonatorului.inсorеspundеrеu regulaottеnbеrgеstеposibilёtransfuzia n|JnumaiasAngеluidе aсeiеagigrupё.Егitroсitеlе grupеio(I)_nuсon{inniсiunaglutinogеnqinu arеloсaglutinarеaiсicu un sеr dеaltеgrupe.Deсi,sAngеlеgrupao(I)poatеitransfuzatgilapersoanеleсuoriсеgrupsangvin.in sеrulsangvingrupaAB(IV)nusuntaglutininе,dеaсееaеritroсitelеaltorgrupеde singе nu vorfiaglutinatе9irеspeсtiv persoanеlorgr.AB (IV)рoatefi transfuzats6ngеdе oriсе gruPб:Rеgulaoffеnbеrgpoatеfiutilizatй doarnumailatransfuziaa0,5litrides6ngеdonator.
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inсazulpiеrdеrilormasivеdе s6ngе, 6ndеstеnесеsarйransfuziaunеiсantitй1i ai marеsAngе,glitininеlеlasmеidonatoruluiu suntsufiсiеntdiluatе n sеrul есipiеntuluiiastfеlpotaglutinaritrосitеlе aсiеntului.inaсеast6 auzб' stеnесеsardе a transfuzaumais6ngеасеia;i gгupй.Grupul sangvin onform isеmuluiABoроatеidеtеrminatu ajutогulrеaсtiеidе aglutinarе.inprеzеntsunt 3 mеtodеdеterminarе grupеidе s6ngеconfoгmsistemuluiBO:-сusеruri standartе;-сu eritroсitеtandartеmеtodaсruсiqatЁ);-сutoliсloniAnti-AqiAnti-B(antiсorpimonoсlonali)
Detеrminarеagruprisаngvinеusеruristandartе
utilizеazйsеruri_tеst dеgrupеlеo(I),A(II),B(III)ndouйsегiidifеritеpеntruiесarеgrupa.n ambelеsеriirеzultatеlеrеbuiеsЁ сoinоiсl6.Sе ia o farfuriеalb6 sau oplaс5prсaresе sсrienumelеpеrsoanеi,sflngеlе йruiasе сrrсеtеaz6qidе lastAnga a drеaptaao distan!6е З*4ц,l;lsе sсriu сifrеlеI, II, III, сarе ndiсisеrurilеtеst.opiсЁfurйsеr-tеst0,1ml) dеgrupa, apliс6 сuopipеtйubсifiaI9ila fеl сu divеrsеpipetеse apliсёsеr-tеstеgr.IIqiIII,rеspесtiva сifтсlеП, III.Apoiсu o baghеti dе stiсlёrесoltеazб,dngedе lapaсiеnt qiapliсй с6tе opiс6furЁmiс6 dе s6ngе5.10 orimai miсidесAtсelе dе sеr)alйturi dе fiесarepiс6turйdе sеr_standart.Fiесarеpiс6tur6dе sеr_tеstamеstесйu un be}iqor е stiсlй.Seaprесiеaz6"reшfltatеlеimp dе5min.:1. Daсй aglutinareaсu sеrul_tеst dеgrupaI,II,ПI n-a avut loс,insеamnйсйеritroсitеle sAngеluiсеrсеtatnuсonfinaglutinogеnеqiеlrеfеrЁ agrupao(I).
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