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Dr. Rossignol Study 2009 HBOT Autism

Dr. Rossignol Study 2009 HBOT Autism

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Published by writingbox
Hyperbaric treatment for children with autism: a multicenter, randomized, double-
blind, controlled trial

Taken from http://www.biomedcentral.com/1471-2431/9/21
Hyperbaric treatment for children with autism: a multicenter, randomized, double-
blind, controlled trial

Taken from http://www.biomedcentral.com/1471-2431/9/21

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Categories:Types, Research
Published by: writingbox on Mar 27, 2009
Copyright:Attribution Non-commercial

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01/30/2013

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Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial
Daniel A. Rossignol
, Lanier W. Rossignol
1
, Scott Smith
1
, Cindy Schneider
2
, Sally Logerquist
2
,Anju Usman
3
, Jim Neubrander
4
, Eric M. Madren
5
, Gregg Hintz
6
, Barry Grushkin
7
, Elizabeth A.Mumper
81
International Child Development Resource Center, Melbourne, FL, USA
2
Center for Autism Research and Education, Phoenix, AZ, USA
3
True Health Medical Center, Naperville, IL, USA
4
Edison, NJ, USA
5
Princess Anne Medical Associates, Virginia Beach, VA, USA
6
Therapeutic Pathways, East Troy, WI, USA
7
Biognosys, Nanuet, NY, USA
8
Rimland Center, Lynchburg, VA, USA
§
corresponding authorEmail addresses:DAR: rossignolmd@gmail.comLWR: dlross7@hotmail.comSS: scott@icdrc.orgCS: cschneider@center4autism.org
 
SL: logerquist@cox.netAU: anju0@yahoo.comJN: drneubrander@drneubrander.comEMM: emmadren@yahoo.comGH: therapeuticpathways@yahoo.comBG: bgrushkin2@cs.comEAM: drmumper@rimlandcenter.com
 
AbstractBackground
Several uncontrolled studies of hyperbaric treatment in children with autism havereported clinical improvements; however, this treatment has not been evaluated to date with acontrolled study. We performed a multicenter, randomized, double-blind, controlled trial toassess the efficacy of hyperbaric treatment in children with autism.
Methods
62 children with autism recruited from 6 centers, ages 2-7 years (mean 4.92±1.21), wererandomly assigned to 40 hourly treatments of either hyperbaric treatment at 1.3 atmosphere (atm)and 24% oxygen (“treatment group”, n=33) or slightly pressurized room air at 1.03 atm and 21%oxygen (“control group”, n=29). Outcome measures included Clinical Global Impression (CGI)scale, Aberrant Behavior Checklist (ABC), and Autism Treatment Evaluation Checklist (ATEC).
Results
After 40 sessions, mean physician CGI scores significantly improved in the treatmentgroup compared to controls in overall functioning (p=0.0008), receptive language (p<0.0001),social interaction (p=0.0473), and eye contact (p=0.0102); 9/30 children (30%) in the treatmentgroup were rated as “very much improved” or “much improved” compared to 2/26 (8%) of controls (p=0.0471); 24/30 (80%) in the treatment group improved compared to 10/26 (38%) of controls (p=0.0024). Mean parental CGI scores significantly improved in the treatment groupcompared to controls in overall functioning (p=0.0336), receptive language (p=0.0168), and eye

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