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Calcium Channel Blockers

Calcium Channel Blockers

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Published by hap hazard
presentation in medical school
presentation in medical school

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Published by: hap hazard on Apr 23, 2013
Copyright:Attribution Non-commercial

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06/28/2014

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CLASSIFICATION
Dihydropyridines
amlodipine felodipine nifedipineisradipine nicardipine nimodipineniterendipine nisoldipine clevidipine(i/v only)
Benzothiazepines
 deltiazem (Na
+
also)
Phenylalkylamines
verapamil (Na
+
also)Bepridil
 –
block Na
+
Ca
2+
& K
+
channels producesdelayed repolarization and prolonged Q-T interval.
 
CALCIUM CHANNELS TYPES
Receptor operated / Ligand gated
 –
e.g IP
3
gatedchannel which causes release of Ca from ER
Voltage Sensitive
Pcerebellar purkinje neuronsNneuronalTlow voltage,transient in opening, presentin neurons and pacemaker cellsLlarge in conductance,
numbers in cardiac& smooth muscles
Have 5 structural sub units
α
1
 
α
2
 
β
 
γ
&
δ
 
 
α
1
is the major sub unit, dihydropyridinesbind only to this sub unit
 Only L type blocked by Ca
2+
channel blockers 

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