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Fluoride Bone Cancer 16

Fluoride Bone Cancer 16

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Published by: mary eng on Apr 28, 2013
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11/07/2013

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PROGRESS REPORT SUMMARY
:\]T NUMBER
ES06000 - 03
PERIOD COVERED BV THIS REPORTFROM THROUGH
9/ 30/ 94
PRINCIPAL INVESTIGATOR OR PROGRAM DIRECTOR
Chest er W. Dougl ass, DMD, PhD
APPLICANT ORGANIZATION
Har var d School of Dent al Medi ci ne
 TITLE OF PROJECT
(Repeat tifle shown in item
1
on first page)
Fl uor i de Exposur e and Ost eosar coma
(SEE INSTRUCTIONS)
Final Data CoUection Figures for Retrospective Aspect of the Study The orthopedie department fromten hospitals nationwide participated ineolleeting datafrom retrospective cases of osteosarcoma and their matched contraIs. Telephone contactwas possible for 673participants, with 23 refusaIs. Telephone interviews were conductedand completed with lliLcases and~matched controls. Fluoride levels inthe drinkingwater were ascertained for aparticipant's complete residential history for 164 cases and346 controls. Fluoride Ievels were unobtainable for 140participants (46 cases and 94controIs) for two reasons; 52participants had lived overseas for aperiod oftime duringtheir life and 88participants didnot return aweIl water sample. To measure fluorideexposure, participants seIf-reported consumption of either municipal water and weUwater, or bottled water at each residential address. The CDC Fluoridation Censusprovided the fluoride levels inthemunicipal water. WeIl water samples were analyzedfor fluoride content atHarvard School of dental Medicine. No attempt to gather thefluoride content ofbottled water was made, assumptions wiU be made inthe analyses.Initial Analyses for the Retrospective Aspect of the Study The foUowing analyses assumed that the fluoride leve1in bottled water was 1.0ppm. Theaverage lifetime exposure offluoride was 0.55 ppm inthe population of cases and 0.53 inthe population of controls (t-test=-0.49, p=0.62). For four matched-pairs analyses, thepoint estimates of the odds ratio (OR) was less than 1. The OR of disease (osteosarcoma)associated with anaverage lifetime exposure greater than 0.7 ppm fluoride was 0.904(CI=0.583, 1.402). The OR associated with and average liftetime exposure greater than 1ppm fluoride was 0.942 (CI=0.568, 1.562). The OR associated with exposure greaterthan 0.7ppm offluoride during the first fifteen years oflife was 0.854 (CI=0.504, 1.448). The OR associated with exposure greater than 1.0ppm offluoride during the first fifteenyears oflife was 0.537 (cI=0.302, 0.956). However, ifwe look at the 19cases and 27controls who atsornepoint intheir life had lived at an address where the fluoride levelwas greater than 1.0ppm, thepoint estimate of the OR was not less than 1. The OR forthe matched analysis was 1.315 (CI=0.603, 2.869). ln an unconditional analysis in whichwe assume bottled water to contain 0.0ppm fluoride, and look at other exposures tofluoride of greater than 1ppm at any time, the OR=2.75 (1.2, 6.4). Included in thatanalysis are 10contraIs and 12cases.Questions Left UnansweredUsing fluoride levels in drinking water to measure fluoride exposure has its limitationsdue to other potential sources of fluoride exposure. Other common sources of fluoride
9/ 29/ 95
PHS 2590 (Rev. 9/91)
(Form Page 6) Page
_1_9_ 
(Use continuation pages if necessary)
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