DETOXIFICATION AND CANCER

The role of chelation and detoxification in the treatment and prevention of cancer

Detoxification

What are you detoxifying & why?

Detoxification Pathways
Drainage vs. elimination
Drainage- from the organ/matrix to the circulation

system
Elimination- From the circulation system out via the GI

Tract, urination, breathing (lungs), skin, & other excretions

Chelation & Detoxification Principles

Patients Health Patients Disease Timing - Seasons Complexity of Toxic State

Detox Philosophy

Antidote Transformation Acceptance Freedom

Detox Principles & Philosophy

Understand the difference between drainage and

elimination and how to support both

Initial preparation - assessment, strategy & planning

with emphasis on seasonal timing

Utilize appropriate support structure and tools Construct realistic goals and proceed slowly

Detox Principles & Philosophy

Follow up program: Maximize benefits of detoxification Smooth transition after detoxification

Freedom - the concept of loosening our grip: Mentally/Emotionally/Spiritually: supports overall detox Physiologically: releasing the toxins from organs & tissues Grasping & letting go Expanding while detoxifying

The Detoxification Cycle

Liver as the starting point Follow circulation

Lungs
Heart/brain Gastrointestinal tract Systemic - joints, etc. Elimination or back to the liver or other tissues

Tools in Detoxification
Diet

Nutritional supplements
Botanicals Acupuncture & Moxibustion

Heat therapies - Infra red saunas

Purging - colonics, enemas, washes Intra venous therapies

Lymph drainage
Meditation Body/Mind Connection

Detoxification Diet
High fiber
High greens Help elimination - liver & large intestines

Catabolic
Organic Modify as needed

Heavy Metal Detoxification Principles

Go slow Appropriate timing Avoid fasting or radical low protein diets while detoxifying

heavy metals

Supplement with minerals Support the body in the process Have a long term maintenance plan

Chelation Guidelines: A Multi-step Graduated Program

Start by Chelating from the blood & GI Tract Once total body burden has decreased, enhance chelation & add organ specific detoxification Support drainage, elimination mechanisms & pathways Support bodys system Minimize side effects & aggravations Gentle & gradual chelation is almost always preferable

Detoxification Supplements
Modified Citrus Pectin/Alginate complex
Medicinal Mushrooms - balanced, multi-nutrient type

formulations
Alpha Lipoic Acid, sulfured amino acids, others Digestive support - herbs, enzymes, probiotics

EDTA, DMSA & DMPS Used for Provocation

Sometimes called a "challenge" or "provoked" heavy metals

test. The ability of EDTA, DMSA or DMPS to mobilize heavy metals stored in body tissues (& therefore not typically present in the circulation) increases the excretion of heavy metals in the urine, leading to more accurate identification of total heavy metal toxicology than hair or blood tests alone. This must be performed by trained medical practitioners, with timed urine collections sent out to a specialized laboratory for analysis.

Safe Natural Chelation

Natural Chelators
More recently natural chelating agents have also been

discovered, such as the use of pectins after the Chernobyl disaster in 1986.
Includes polyuronide soluble fibers (Modified Citrus Pectin &

kelp alginates), Vitamin C, natural thiol compounds & sulfur containing amino acids, kelp derived alginates & even herbs such as cilantro/coriander (Coriandrum sativum).
These have properties that bind with metallic ions so that the ion is held by

several chemical bonds. This renders it much less chemically reactive, producing a complex that is water soluble allowing it to be excreted harmlessly by the body.

Natural Chelation is Significantly Safer

Alpha Lipoic Acid (ALA): Rare cases of allergic reaction. Other

possible side effects include headache, muscle cramps, & a feeling of pins & needles in the body. Not to be used in initial state of chelation.
Vitamin C: Rare cases of gastrointestinal complaints. These side

effects normally stop as soon as high potency intake is reduced or stopped.

Modified Citrus Pectin: No known adverse effects other than

occasional loose stools.

Alginates: No documented adverse effects

Modified Citrus Pectin (MCP) in Chelation and Detoxification

Clinical data indicates that MCP functions as a gentle chelator of

heavy metals.
case studies.

The detoxification properties have been confirmed in clinical trials & MCP has shown in clinical studies to increase the urinary excretion of

toxic metals such as lead, cadmium, arsenic & mercury.

the body burden as shown in a clinical trial.

Long-term use of this gentle safe chelator could effectively reduce The ability of MCP and modified Alginates to remove heavy metals &

environmental toxins on an ongoing basis has been shown to be of significant clinical benefit in multiple case studies.

Chemical Properties of Alginates & Pectin

Citrus Pectin Chemical Structure

Pectin has neutral sugar chains that branch off from the main chain of galacturonic acid. Some of the galatcuronic acid groups have an additional methyl group (CH3-) associated with them. This is called esterification and it reduces chelation potential.
O O C O O HO O C O O Ar HO OH Ar OH O HO OH O C O O HO OH Ar OH O C O O Rh OH OH HO OH HO OH HO OH C OH O O O OH O C O O OH O C O O

CH3 O

Esterified Galacturonic Acid

O C O OH

OH

OH

Neutral Sugars
Rh

Galaturonic Acid Group

Ar

Rhamnose Arabinose

Alginates have a similar linear structure to pectin without the neutral sugar side branches. Instead of galacturonic acid, alginate is made up of trepeating blocks of mannuronic and guluronic acid.

A class of complex polysaccharide compounds known as polyuronides. Polyuronides are long chains of repeating sugar acid groups such as galacturonic acid (pectin) or mannuronic & guluronic acid (alginates). Polyuronides are proven chelators of toxic metals, pesticides & herbicides, and have been used in humans exposed to lead & radioactive metals as well as in the clean-up of environmental pollution for over 40 years.

Chelation Egg Box Theory

Mechanism of Action
In solution, the long fiber chains stack together in groups forming pockets where metal cations can complex with the fiber. This stacked formation is sometimes referred to as an "egg box confirmation". PCC chain (comprised of alginate or pectate)

Metal Complex Formation

mercury (Hg2+)

lead (Pb2+) cadmium (Cd2+)

Once the metals are bound to the fiber they can easily be removed from the body via the urine or feces.

Polyuronides form stacks in solution in what is known as an egg box structure. Each pocket of the egg carton contains a positively charged ion to balance the negatively charged chains. Normally the positive ions are sodium & potassium. However, toxic metals especially lead, mercury, cadmium, & radioactive metals have a higher affinity for polyuronides than the essential ions like calcium, magnesium, & potassium. Toxic metal ions become trapped in the egg box structure & are eliminated from the body.

Stage I Detoxification
During the first stage of detoxification, avoid introducing agents that can penetrate into the tissues & bind heavy metals to them. The concern is that they can pull heavy metals including mercury from the circulation into the tissues, especially the brain.

Stage I Detoxification Continued

First chelate using MCP, or Modified Citrus Pectin/Alginate

complex to slowly reduce the overall heavy metal burden on the tissue level for 2-4 weeks. During the initial chelation stage, higher dosages of such a combination are needed. For maintenance & long term prevention, lower dosages are sufficient. Due to ongoing exposure to heavy metals such as lead & mercury, there is great benefit to using such a preparation on a long term basis. Modified Citrus Pectin/Alginate complex provides on-going gentle chelation systemically in the blood stream as well as in the digestive tract.

The Effect of Modified Citrus Pectin on the Urinary Excretion of Toxic Metals
Eliaz I, Hotchkiss AT, Fishman ML, Rode D.3 Amitabha Medical Clinic & Healing Center, Sebastopol, California, USA. Eastern Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Wyndmoor, PA 19038,3University of California, Davis, CA, USA. Phytother Res. 2006 20(10):859-64.

Methods: Prior to oral administration of MCP, the subjects collected

a 24 hour urine sample for baseline measurements. Twenty four hour urine samples were also collected on day one & day six. The subjects ingested 15 grams of Modified Citrus Pectin (MCP) each day for five days & 20 grams on day six. Urine samples were analyzed by ICP-MS (inductively coupled plasma-mass spectrophotometer). Results: Lead, mercury, cadmium & arsenic increased significantly in urine analysis. Essential minerals were not changed significantly. No side effects were reported.

Results: Modified Citrus Pectin & Urinary Excretion of Toxic Elements - Day One
Results Day One

Urinary Excretion of Elements - Day One

250

(Percent Change from Day Zero) #

200

p<.05

# p<.1

% Change from Day Zero

150

100

50

0 Al Sb As Cd Pb Hg Sn

-50

Element

Results: Modified Citrus Pectin & Urinary Excretion of Toxic Elements - Day Six
Results Day Six

Urinary Excretion of Elements - Day Six

700 600

(Percent Change from Day Zero) #

% Change from Day Zero

p<.05

# p<.1

500 400 300 200 100 0 Al Sb As Cd Pb Hg Sn

Element

Results Summary
In the first 24 hours of MCP administration the urinary excretion of

arsenic increased significantly (30% over baseline/day zero, p<0.05). approached significance (50% & 130% over baseline respectively; p<0.1). On day six, urinary excretion was significantly increased for cadmium (50% over baseline, p<0.05) with tin approaching significance (130% approached significance; p < 0.1).

In this same period, the excretion of mercury & cadmium

In addition, lead showed a dramatic increase in excretion (460% over

baseline) with p=0.05

No significant changes in the excretion of Al, Ca, Cu, Mg, Zn, Fe, Se,

Pt, Be, Bi, Tl, Th, U & Sb were observed.

No Side effects were reported.

Modified Citrus Pectin Decreases the Total Body Burden: A Pilot Human Clinical trial
Eliaz I. Amitabha Medical Clinic & Healing Center, Sebastopol, California, USA. EcoNugenics, Santa Rosa, California, USA. 228th ACS National Meeting, Philadelphia, PA. 2004.

Methods: Oral intake 5 g Modified Citrus Pectin/3x day for

4-10 months. Base line body burden and change measured with DMPS challenge (250mg i.v. followed by 6 hr. urine collection). Results: All subjects showed significant decrease in Mercury levels. Average decrease was 62.17%, ranging between 38.13% & 74.83% (p=0.0313). No significant side effects were noted.

Study Conclusion
Percent Reduction in Mercury from Baseline
Percent Reduction in Mercury from Baseline
80% 70% 60% 50% 40% 30% 20% 10% 0%
Patient A Patient B Patient C Patient D Patient E 38.10%

MCP was effective in

67.90%

72.80%

74.80%
57.30%

decreasing the total body burden of Mercury in all subjects.

MCP is a promising
4 months 6 months6.5 months

10 months 4.5 months

systemic gentle chelator of heavy metals that can be used on an on going basis.

MCP Intervention Individual Results

The Role of Modified Citrus Pectin as an Effective Chelator of Lead in Children Hospitalized with Toxic Lead Levels
Zhao ZY, Liang L, Fan X, Yu Z, Hotchkiss AT, Wilk BJ, Eliaz I. Childrens Hospital, Zhejiang University, School of Medicine, Hangzhou, Republic of China, Centrax International, Inc, San Francisco, California, USA. Eastern Regional Research Center, Agricultural Research Services, US Department of Agriculture, Wyndmoor, Pennsylvania, USA. EcoNugenics, Inc. Santa Rosa, California, USA. Altern Ther Health Med. 2008 14(4):34-8.

Lead in 24 Hour Blood Serum

60

P Value = 0.0016
50

40

30

20

10

0 1 2 3 4 5 6 7

Figure 1 Blood serum lead concentration (ug/dL) measured in blood serum by GFAAS before (Blue) and after (Red) Modified Citrus Pectin treatment (5 grams three times daily) in 7 hospitalized children 5-12 years of age. No side effect reported.

Lead in 24 Hour Urine Excretion

140 120

P Value = 0.0007

100

80

60

40

20

0 1 2 3 4 5 6 7

Figure 2 Lead levels (g/dL) measured in 24-hour urine excretion by GRAS before (Blue) and after (Yellow) Modified Citrus Pectin treatment (5 grams three times daily) in 7 hospitalized children 5-12 years of age. No side effects reported.

Stage II Detoxification
Support heavy metal discharge and purge heavy metals while the body is going through a detoxification process. We can foster this process by:
Removal & excretion of heavy metals from the tissue. Preventing re-absorption of heavy metals secreted via the bile to

the gut. Binding circulating heavy metals, neutralizing & preventing reabsorption in the gut. Aiding the liver & the detoxifying enzymes in the body, support drainage & elimination. Supporting the bodys energy/vitality/strength to allow the body to follow through & successfully chelate the heavy metals. Supporting tissues where the chelation process can create side effects, such as the brain.

Stage II Supplementation: Detox Complete

Poly botanical/thiols/nutrient formula is the second stage in a

unique, two-part integrated detoxification system that broadens the gentle systemic chelation process.

Designed as a complimentary formula to be used after 2-4

weeks of gentle chelation with Modified Citrus Pectin/Alginate complex. by addressing multiple facets of chronic heavy metal toxicity. combination of vitamins, nutrients & herbs that support detoxification from the tissues & organs and aids in liver detoxification, promoting elimination through both the bile/intestines & the urinary tract.

Poly botanical/thiols/nutrient formula supports detoxification It fosters systemic chelation by providing a comprehensive

Stage II Supplementation: Detox Complete

Integrative Medicine & the Role of Modified Citrus Pectin/Alginates in Heavy Metal Chelation & Detoxification - Five Case Reports
Eliaz, I, Weil, E, Wilk, B. Amitabha Medical Clinic & Healing Center, Sebastopol, California, USA. EcoNugenics, Santa Rosa, California, USA. Forsch Komplementmed. 2007 Dec;14(6):358-64.

Five Case Reports: Results

Percent Decrease in Heavy Metals Pb = Lead, Hg = Mercury, (Mo) = Months 75% Average Decrease, P Value = 0.026

100%
100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 49% 83% 83%

74%
58%

Pb (3Mo) Pb (6Mo) Hg (6Mo) Hg (6Mo) Hg (6Mo) Hg (12Mo)

Detoxification Guidelines
Start by Chelating from the blood & GI Tract Once Total Body Burden has decreased, enhance chelation &

add organ specific detoxification

Support drainage, elimination mechanisms & pathways Support bodys system Minimize side effects & aggravations

Gentle & gradual chelation is almost always preferable

Detoxification Summary
Define your goals - patient & practitioner Proper timing Multi faceted program

Post detoxification follow up

Repeat cleanse during spring & fall

Evaluate success - physical, emotional &

mental/psychological/spiritual

LINKS BETWEEN CANCER AND DENTAL HEALTH

Specific Dental Risk Factors in Cancer

Root Canals Mercury amalgam fillings Infection Inflammation

Links between Cancer and Dental Health

Research shows generalized links between periodontal

disease and certain cancers

Traditional Chinese Medicine demonstrates

relationships between teeth and organ systems

Relationships between teeth and organs

Periodontal Disease Linked to:

Cancer

Systemic Inflammation
Heart Disease Diabetes Autoimmune Disease Osteoporosis Allergies Lung Conditions Obesity Other conditions

PERIODONTAL DISEASE, INFLAMMATION AND CANCER

Research Highlights

The Association of Dental Plaque with Cancer Mortality in Sweden

Soder B, Yakob M, et al. Dept. of Dental Medicine, Karolinska Institutet, Huddinge, Sweden BMJ Open 2012;2;e001083. doi:10.1136/bmjopen-2012-001083

Objectives: To study whether the amount of dental plaque,

which indicates poor oral hygiene and is a potential source of oral infections, correlates with premature death from cancer.
Methods: Prospective cohort study. 1390 randomly selected

healthy young Swedes followed from 1985 to 2009.

The Association of Dental Plaque with Cancer Mortality in Sweden

Soder B, Yakob M, et al. Dept. of Dental Medicine, Karolinska Institutet, Huddinge, Sweden BMJ Open 2012;2;e001083. doi:10.1136/bmjopen-2012-001083

Results: 4.2% of participants died during the study. Amount of dental plaque between those who died and those who survived was statistically significant with 1.79 times the overall risk of death via scattered malignancies in men and breast cancer in majority of women. Conclusion: Increased amount of dental plaque may be associated with increased cancer mortality. Further studies are warranted.

Chronic Periodontitis and the Incidence of Head and Neck Squamous Cell Carcinoma
Tezal M, et al. Depts. Oral Diagnostic Sciences, Oral Biology, Social and Preventive Medicine, Otolaryngology, S.U.N.Y. New York, USA Cancer Epidemiol Biomarkers Prev 2009 18;2406.

Objective: To assess the effect of chronic periodontitis on head

and neck squamous cell carcinoma (HNSCC). Methods: 473 HNSCC patients studied btw 1999-2005. Periodontitis measured by alveolar bone loss (ABL). Results: Each millimeter of ABL was associated with >4-fold increase risk of HNSCC. Chronic periodontitis may be an independent risk factor for HNSCC.

Periodontal Disease May Associate with Breast Cancer

Soder B, et al. Dept. of Dental Med., Division of Periodontology, Karolinska Institutet, Huddinge, Sweden. Breast Cancer Res Treat. June 2011; 127(2):497-502

Objective: To evaluate the association between periodontal

disease, missing molars and breast cancer. Methods: Prospective study of 3,273 subjects ages 30-40 at baseline. Results: Chronic periodontal disease accompanied by missing molars associates statistically with increased incidence of breast cancer.

A Review of the Relationship Between Tooth Loss, Periodontal Disease, and Cancer
Meyer M, et al. Harvard School of Public Health Dept. of Epidemiology, Boston, MA. USA Cancer Causes Control 2008 19:895-907

Objectives: A review of 18 published studies demonstrating

relationships and possible mechanisms of action between tooth loss, periodontal disease and various cancers. Controlled for smoking, demographics and other possible confounding factors.

Summary
Relationships between teeth and organs Relationships between periodontal disease, inflammation and cancer Relationships between heavy metal toxicity, inflammation and cancer Natural agents with anti-inflammatory/anti-microbial/anticancer properties: Modified Citrus Pectin Tibetan Herbal Formula Honokiol Vitamin D3