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(2) The innate immune system is not specific in its response and reacts
equally well to a variety of organisms, whereas the adaptive immune system
is antigen-specific and reacts only with the organism that induced the
response.
Artificial: immunization
(vaccination) with some product
derived from the infectious agent
(e.g. toxoid, killed cells, structural
components of cells, inactivated or
attenuated viruses, etc.).
B-lymphocytes T-lymphocytes
•Peyer’s patches
Cutaneous Associated Lymphoid Tissue
Basophils
Neutrophils
Eosinophils
Agranulocytes
Lymphocytes Monocytes
Regulation of Hematopoeiesis
• The less a molecule is like a self-molecule, the more immunogenic it is likely to be.
• Conversely, if a pathogen produces a surface molecule that is very like one of your
own molecules, you will have a much harder time recognizing and responding to it
(like a wolf in sheep's clothing.)
• Even worse, if a pathogen produces a protein that resembles one of your own, you
may produce antibodies to your own protein when you develop immunity to the
pathogen.
• If your immune system does not get exposed early on to one of your own tissue
components, it will be able to produce an immunogenic response to it (lens
crystallins, for example).
2. Molecular Size
• Generally, the bigger the molecule, the more likely it is to trigger an immune
response.
1. Chemical Constitution
3. Nutritional Status.
5. Dosage
• Series of doses more effective than a single one (immunization series and booster
shots).
• GI tract least effective - although you may have had Sabin vaccine.
• Other routes (IV, IM, IP) will expose different immune organs first.
Different anatomic sites have different kinds of sentinel dendritic cells, macrophage
sub-types, and different kinds of circulating lymphoid cells.
Properties of Adjuvants
Peptide
Ag presentation on MHC class-I molecule
MHC class- II molecule
X-Ray crystallography structure
Peptide
Ag presentation on MHC class-II molecule
Diagram showing MHC
class I-peptide binding
motif:-
Diagram showing MHC
class II-peptide binding
motif:-