Advanced researchon the health beneﬁtof reduced water
Sanetaka Shirahata*,Takeki Hamasaki andKiichiro Teruya
Department of Bioscience and Biotechnology,Faculty of Agriculture, Kyushu University, 6-10-1Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan(Tel.:
81 92 642 3045; fax:
In Japan, research on functional water, especially on reducedwater, is developing at a rapid pace. Reduced water such aselectrochemically reduced water and natural reduced watercan scavenge reactive oxygen species in cultured cells.Reduced waters are expected to have preventive and positiveeffects on oxidative stress-related diseases such as diabetes,cancer, arteriosclerosis, neurodegenerative diseases, and sideeffects of hemodialysis. It has been suggested that the activeagents in reduced water are hydrogen (atoms and molecules),mineral nanoparticles, and mineral nanoparticle hydrides.
Introduction: electrochemically reduced water isbeneﬁcial for health
In the ﬁeld of food science and technology, water is animportant ingredient inﬂuencing taste, rheology and preser-vation of foods. Research on functional foods is currentlypopular; however, it is not yet well known that drinkingwater also has physiological functions, and that there aresome health-beneﬁcial effects of water (Shirahata, 2002,2004). In the past decade, the decrease in the quality of tap water because of pollution of the global environmentover time has become a major social problem. Air pollutionaffects water in soils, rivers, and farm products by acid rain.Chemicals in polluted water are considered to generateoxidative stress in the placenta of pregnant women, andthis can cause various types of diseases in newborns(Obolenskaya
, 2010).The human body is approximately 60
80% water. Thefunction of water in the body is mainly classiﬁed as fol-lows. (1) The water molecule itself: ﬂowing water affectscellular function and both development and functions of organs (Hirokawa, Tanaka, Okada, & Takeda, 2006; Hove
), hydrogen atoms (active hydrogen[H]), hydrogen anions (H
), hydrogen molecules (H
),oxygen molecules (O
), and reactive oxygen species(ROS); and (3) molecules dissolved in water, such as min-eral ions, mineral nanoparticles, organic and inorganiccompounds, and gases.Functional water is activated water exhibiting speciﬁcfunctions. There are many activation methods such as elec-trolysis, treatment with a magnetic ﬁeld, light irradiation,ultrasonication, bubbling with gases, strong water ﬂow andcollision, and treatment with some types of minerals orrocks. Functional water is deﬁned by The Functional WaterAssociation of Japan as water in which both treatment andfunction have been scientiﬁcally demonstrated or reproduc-ible useful functions have been demonstrated amongartiﬁcially treated waters. Among functional waters, electro-lyzed water has been mostly investigated. Electrochemicallyreduced water (ERW) is produced near a cathode and elec-trochemically oxidized water (EOW) is produced near ananode. Potable ERWis a health-beneﬁcial water as discussedhere. EOW is also termed electrolyzed acidic water and isfunctional water exhibiting a sterilizing action, mainly dueto hypochlorous acid, chlorine gas, and ozone (Bari,Sabina, Isobe, Uemura, & Isshiki, 2003)(Fig. 1A).
Potable ERW (pH 8
10) is popular as a health-beneﬁcial water in Japan. ERW is also termed alkaline elec-trolyzed water, alkali-ionic water, alkaline cathodic water,and alkaline ionized water, based on its physicochemicaland physiological aspects. ERW exhibits an alkaline pH,is hydrogen molecule-rich, and has a negative oxida-tion
reduction potential (ORP) and reactive oxygen spe-cies (ROS)-scavenging activity (Shirahata
, 2007).Studies on the functions of ERW were initiated in Japanin 1931, and its application to agriculture was ﬁrst
This article was accepted as part of the Food Science in Japan specialissue.* Corresponding author.
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