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Table Of Contents

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FDA Indications
Chemical Structure
SSRI Structures
Switch Rates of SSRIs
Efficacy
Pharmacodynamics
Dose-response Curves
% Blockade of 5-HT
Possible Clinical Consequences of 5-HT Reuptake Blockade
Serotonin
Possible Clinical Consequences of NE Reuptake Blockade
Norepinephrine
Selectivity for 5-HT vs. NE Transporter
Possible Clinical Consequences of DA Reuptake Blockade
Dopamine
Possible Clinical Consequences of Muscarinic Blockade
Acetylcholine
Possible Clinical Consequences of Histamine (H1) Blockade
Histamine (H1)
Histamine (H1)-Receptor Binding
Medication
fluoxetine (Prozac)
venlafaxine (Effexor)
nefazodone (Serzone)
s-citalopram (Lexapro)
Summary
Pharmacokinetics of the SSRIs
Issues to Consider in the Elderly
Pharmacokinetic Parameters of the SSRIs
Half-lives of the SSRIs
P-450 Enzymes and the SSRIs (at least moderate activity >50%)
CYP2D6
CYP2D6 Inhibition in Vitro
CYP3A4
CYP3A4 Inhibition in Vitro
CYP1A2
CYP1A2 Inhibition in Vitro
Active Metabolites and the SSRIs
Auto-inhibition of Metabolism and the SSRIs
Sertraline vs. Paroxetine n=176 n=177
Sexual Dysfunction
Rates of Sexual Dysfunction
Cost Considerations
sertraline (Zoloft)
paroxetine (Paxil)
fluvoxamine (Luvox)
citalopram (Celexa)
S-citalopram (Lexapro)
Beyond the SSRIs
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Ssris and its effects

Ssris and its effects

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Published by Hector Raul
SSri antidepressants
SSri antidepressants

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Categories:Types, School Work
Published by: Hector Raul on May 13, 2013
Copyright:Attribution Non-commercial

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05/13/2013

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