Welcome to Scribd, the world's digital library. Read, publish, and share books and documents. See more
Download
Standard view
Full view
of .
Look up keyword or section
Like this
61Activity
0 of .
Results for:
No results containing your search query
P. 1
Quiz Hematology Oncology Part 2 of 2

Quiz Hematology Oncology Part 2 of 2

Ratings: (0)|Views: 4,236 |Likes:
Published by MedShare
Quiz Hematology Oncology Part 2 of 2
Quiz Hematology Oncology Part 2 of 2

More info:

Published by: MedShare on Apr 15, 2009
Copyright:Attribution Non-commercial

Availability:

Read on Scribd mobile: iPhone, iPad and Android.
download as PDF or read online from Scribd
See more
See less

10/15/2014

pdf

 
Hematology & Oncology Part 2 14Mar2009DO NOT DISTRIBUTE - 1 -
Hematology/Oncology #1 – Immunology: Cancer
1) Which of the following cases occurring during B cell development would be lethal for the lymphocyte?a) Translocation of an oncogene resulting in permanent activation of the oncogene b) Translocation of an oncogene with an immunoglobulin gene promoter c) Chromosomal breaks during class switching and somatic hypermutationd) Joining of chromosomal segments from different chromosomese) Repair of chromosomal breaks during immune-receptor gene recombination2.1) What is the role of the oncogene c-myc, which is commonly translocated to theimmunoglobulin heavy chain on chromosome 8?a) Stimulates cell apoptosis b) Stimulates lymphocyte proliferationc) Permanently prevents cell divisiond) Protects against cell apoptosise) Destroys cancer cells2.2) What is the role of the oncogene Bcl-2, which is commonly translocated tochromosomes 14 and 18?a) Stimulates cell apoptosis b) Stimulates lymphocyte proliferationc) Permanently prevents cell divisiond) Protects against cell apoptosise) Destroys cancer cells3.1) Which of the following viruses is associated with Kaposi sarcoma, which isspecifically seen in immunocompromised patients (e.g. AIDS)?a) Human Herpes Virus 3 (VZV) b) Human Herpes Virus 4 (EBV)c) Human Herpes Virus 5 (CMV)d) Human Herpes Virus 8 (HHV-8)e) Human T lymphocyte virus 1 (HTLV1)3.2) Which of the following is a retrovirus that encodes Tax protein, leading to a raremalignancy?a) Human Herpes Virus 3 (VZV) b) Human Herpes Virus 4 (EBV)c) Human Herpes Virus 5 (CMV)d) Human Herpes Virus 8 (HHV-8)e) Human T lymphocyte virus 1 (HTLV1)3.3) Burkitt lymphoma is a consequence of polyclonal activation of B cells by bothmalaria and which of the following?a) Human Herpes Virus 3 (VZV) b) Human Herpes Virus 4 (EBV)c) Human Herpes Virus 5 (CMV)d) Human Herpes Virus 8 (HHV-8)e) Human T lymphocyte virus 1 (HTLV1)4.1) Monoclonal gammopathy of undetermined significance (MGUS) are due tomonoclonal immunoglobulins produced in response to some infections. They may also be present in what healthy population?
 
Hematology & Oncology Part 2 14Mar2009DO NOT DISTRIBUTE - 2 -a) Infants b) Childrenc) Hospital workersd) Adultse) Elderly4.2) How is lymphoma usually diagnosed?a) Morphology in blood or bone marrow b) Presence of T cell receptor genesc) Abnormal monoclonal cellsd) Lymph node biopsye) Flow cytometry4.3) How is chronic lymphocytic leukemia (CLL) distinguished?a) Morphology in blood or bone marrow b) Presence T cell receptor genesc) Abnormal monoclonal cellsd) Lymph node biopsye) Flow cytometry4.4) How is acute lymphocytic leukemia (ALL) usually diagnosed?a) Morphology in blood or bone marrow b) Presence T cell receptor genesc) Abnormal monoclonal cellsd) Lymph node biopsye) Flow cytometry4.5) How is lymphoid malignancy diagnosed?a) Morphology in blood or bone marrow b) Presence T cell receptor genesc) Abnormal monoclonal cellsd) Lymph node biopsye) Flow cytometry5) What type of tumor antigen is involved in tyrosinase-secreting melanocytes?a) Developmental proteins b) Lineage-specific proteinsc) Viral proteinsd) Proteins produced through translocationse) None of the above6) Which of the following tend to be the most immunogenic as they are not present in anormal individual?a) Developmental proteins b) Lineage-specific proteinsc) Viral proteinsd) Proteins produced through translocationse) None of the above7) What immune cells are required to eradicate solid tumors?a) Neutrophils b) Lymphocyte B cellsc) Lymphocyte T cells
 
Hematology & Oncology Part 2 14Mar2009DO NOT DISTRIBUTE - 3 -d) Lymphocyte NK cellse) Macrophages8) Tumors are able to evade the adaptive immune system by losing the ability to presentantigen to T cells or by decreasing the expression of major histocompatibility complex(MHC). Cells expressing low levels of MHC may be targeted for destruction by whattype of immune cell, acting as a backup system?a) Neutrophils b) Lymphocyte B cellsc) Lymphocyte T cellsd) Lymphocyte NK cellse) Macrophages9) Infusions of anti-CD20 monoclonal antibodies (passive immunotherapy) can reduce or cure up to 50% of which of the following?a) B cell lymphoma b) T cell lymphomac) NK cell lymphomad) Lymphomatoid papulosise) Sézary disease10) An infusion of which of the following would activate T cells directly (activeimmunotherapy), but has side effects including capillary leak syndrome?a) Cytokine IL-2 b) Cytokine interferons (IFN)c) Cytokine IL-10d) Cytokines IL-1 and IL-18e) Lymphokine-activated killer (LAK) cells
Hematology/Oncology #2 – Pathology
1.1) What is the most common type of non-Hodgkin lymphoma in the United States,which have a characteristic t(14;18) and cells that are awry or with effacement?a) Acute lymphoblastic leukemia (ALL) b) Chronic lymphocytic leukemia (CLL)c) Small lymphocytic leukemia (SLL)d) Follicular lymphomae) Diffuse large B-cell lymphoma1.2) What is the type of the most common primary tumor arising in bone of adults?a) Burkitt lymphoma b) Mantle cell lymphoma (MCL)c) Marginal zone lymphoma (MALToma)d) Plasma cell neoplasms (e.g. multiple myeloma)e) Lymphoplasmacytic lymphoma (Waldenström macroglobulinemia)2) Which of the following type for Hodgkin Disease is the most common?a) Nodular sclerosis b) Mixed cellularityc) Lymphocyte-richd) Lymphocyte-depletione) Lymphocyte predominance (NLPHL)

Activity (61)

You've already reviewed this. Edit your review.
ritz751 liked this
1 thousand reads
1 hundred reads
bryfar liked this
adambridger liked this
Jeffrey Viernes liked this
Adeline N. Omene liked this
Adeline N. Omene liked this
Keisha Curling liked this

You're Reading a Free Preview

Download
scribd
/*********** DO NOT ALTER ANYTHING BELOW THIS LINE ! ************/ var s_code=s.t();if(s_code)document.write(s_code)//-->