Welcome to Scribd, the world's digital library. Read, publish, and share books and documents. See more
Download
Standard view
Full view
of .
Look up keyword or section
Like this
26Activity
0 of .
Results for:
No results containing your search query
P. 1
Quiz Neuroscience Part 4 of 4

Quiz Neuroscience Part 4 of 4

Ratings: (0)|Views: 1,927|Likes:
Published by MedShare
Quiz Neuroscience Part 4 of 4
Quiz Neuroscience Part 4 of 4

More info:

Published by: MedShare on Apr 15, 2009
Copyright:Attribution Non-commercial

Availability:

Read on Scribd mobile: iPhone, iPad and Android.
download as PDF or read online from Scribd
See more
See less

05/17/2013

pdf

 
 Neuroscience Part 4 14Mar2009DO NOT DISTRIBUTE - 1 -
Neuro #1 – Pharmacology: CNS Drugs (Chapter 21)
1) When enough excitatory postsynaptic potentials (EPSPs) are generated, ____ of themembrane occurs and an action potential is generated. Inhibitory postsynaptic potentials(IPSPs) involve ____ of the membrane and a selective increase in membrane permeability to ____ ions.a) Depolarization; Hyperpolarization; Na+ & K+ b) Depolarization; Hyperpolarization; Cl-c) Hyperpolarization; Depolarization; Na+ & K+d) Hyperpolarization; Depolarization; Cl-2) Which of the following correctly describes the order in which metabotropic receptorscause the activation of ion channels?a) Receptor => Diffusible messenger => Activating enzyme => G-protein b) Receptor => G-protein => Diffusible messenger => Activating enzymec) Receptor => G-protein => Activating enzyme => Diffusible messenger d) Receptor => Activating enzyme => Diffusible messenger => G-proteine) Receptor => Activating enzyme => G-protein => Diffusible messenger 
Match the channel blocker with the ion channel site of action:
3.1) Nicotinic ACh receptor ligand a) Tetrodotoxin (Puffer fish)3.2) Ca++ voltage N-type channel b) Apamin (Honeybee)3.3) Na+ voltage channel from outside c) Omega conotoxin (Pacific cone snail)3.4) Glycine receptor ligand d)
!
-bungarotoxin (Marine snake)3.5) Small Ca++ activated K+ channel e) Strychnine (Indian plant)3.6) Which of the following describes how strychnine affects ion channels?a) Competitive antagonist b) Non-competitive antagonistc) Irreversible antagonistd) Competitive agoniste) Non-competitive agonist3.7) Which of the following describes how
!
-bungarotoxin affects ion channels?a) Competitive antagonist b) Non-competitive antagonistc) Irreversible antagonistd) Competitive agoniste) Non-competitive agonist4) If the resting potential of a given membrane is -70mV, which of the following bestdescribes how an inhibitory postsynaptic potential (IPSP) of 20mV would affect themembrane?a) Depolarize the membrane, moving it to -50mV b) Depolarize the membrane, moving it to -90mVc) Hyperpolarize the membrane, moving it to -50mVd) Hyperpolarize the membrane, moving it to -90mV5) After exposure to a sarin (GB) nerve agent at a mass-casualty incident scene, a paramedic self-administers a Mark-1 kit, containing auto-injectors of atropine and pralidoxime chloride (2-PAM). The affects seen by exposure to sarin are similar to pyridostigmine, neostigmine, and physostigmine. 2-PAM works as an antidote to theaffects of sarin in the neuromuscular junction, effectively:
 
 Neuroscience Part 4 14Mar2009DO NOT DISTRIBUTE - 2 -a) Prevents the movement of Ca++ b) Blocks acetylcholinec) Blocks cholinesterased) Reactivates acetylcholinee) Reactivates cholinesterase6) Which of the following is a likely and beneficial role of recurrent neurons?a) Cause excessive neurotransmitter release b) Prevent any neurotransmitter releasec) Prevent excessive neurotransmitter released) Prevent too little neurotransmitter release7.1) Which of the following criteria for neurotransmitter identification would useselective pharmacologic antagonism to determine the manner in which a synapticallyreleased transmitter is acting?a) Localization of neurotransmitter  b) Release of neurotransmitter c) Synaptic mimicry of neurotransmitter 7.2) Which of the following criteria for neurotransmitter identification would involveelectrically or chemically stimulating a slice of brain tissue and measuring substancesnear the stimulated area?a) Localization of neurotransmitter  b) Release of neurotransmitter c) Synaptic mimicry of neurotransmitter 
Match the following agonist/receptor type with the transmitter:
8.1) NMDA a) Acetylcholine8.2) Bromocriptine b) Dopamine8.3) Nicotine c) GABA8.4) Bethanechol d) Glutamate8.5) Kainic acid e) Serotonin8.6) Taurine, B-alanine f) Glycine8.7) 2-methyl-5-HT8.8) Muscimol, Baclofen
Neuro #2 – Pharmacology: Sedatives- Hypnotics (Chapter 22)
1) Generalized CNS depression produced by sedative-hypnotics can depress respiratoryand vasomotor centers in what part of the brain, leading to coma and death?a) Medulla b) Ponsc) Midbraind) Diencephalone) Cerebellum2) Which of the following has an active metabolite seen during degradation?a) Zolpidem b) Zaleplonc) Phenobarbitald) Diazepame) Flumazenil
 
 Neuroscience Part 4 14Mar2009DO NOT DISTRIBUTE - 3 -3.1) Which of the following GABA-A subunits is involved in the benzodiazepine bindingsite?a)
!
subunit b)
"
subunitc)
#
subunitd)
$
subunite)
%
subunit3.2) The chloride channels is triggered by binding of GABA to which of the followingsubunits?a)
!
&
"
  b)
"
&
#
 c)
#
&
$
 d)
$
&
%
 e)
%
&
!
 4.1) Which of the following describes the action of benzodiazepines?a) Increase frequency of GABA-mediated Cl- channel opening b) Increase duration of GABA-mediated Cl- channel openingc) Increase frequency of GABA-mediated Cl- channel opening and block glutamic acidd) Increase duration of GABA-mediated Cl- channel opening and block glutamicacid4.2) Which of the following describes the action of barbiturates?a) Increase frequency of GABA-mediated Cl- channel opening b) Increase duration of GABA-mediated Cl- channel openingc) Increase frequency of GABA-mediated Cl- channel opening and block glutamic acidd) Increase duration of GABA-mediated Cl- channel opening and block glutamicacid5) Low dose benzodiazepines and barbiturates exert a calming affect with anxiety relief (sedation). Higher doses will induce sleep (hypnosis). During hypnosis induced bysedative-hypnotics, which of the following is increased?a) Time to fall asleep b) Duration of stage 2 NREM sleepc) Duration of REM sleepd) Duration of stage 4 NREM slow-wave sleepe) Psychomotor and cognitive functions6.1) Which of the following is NOT characteristic of physiological dependence to a drugwhen the user stops taking the drug?a) Anxiety b) Tremorsc) Compulsiond) Seizurese) Hyper-reflexia6.2) Sedative-hypnotics are NOT commonly associated with development of tolerance.a) True b) False

Activity (26)

You've already reviewed this. Edit your review.
1 hundred reads
1 thousand reads
Thomas Oliver liked this
reddragon2472 liked this
Lara Shnoudi liked this
leone_baptiste liked this
Shin Whiteman liked this
brownhair liked this
Bea Lau liked this

You're Reading a Free Preview

Download
scribd
/*********** DO NOT ALTER ANYTHING BELOW THIS LINE ! ************/ var s_code=s.t();if(s_code)document.write(s_code)//-->