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HH
++
SECRETION ANDSECRETION ANDACID BASEACID BASEBALANCEBALANCE
Prof Harbindar Jeet SinghProf Harbindar Jeet SinghFaculty of MedicineFaculty of MedicineUniversiti Teknologi MARAUniversiti Teknologi MARA
 
 
OBJECTIVES1.Explain the importance of regulation of pH and the role of thekidneys and lungs•Explain the Henderson Hasselbach equation•Renal handling of H
+
•Explain acidosis and alkalosis.
 
 
Acid base balanceThis in essence actually means regulating the H
+
concentration.An increase or decrease in the H
+
concentration can affect normalcell function.The normal H
+
concentration in arterial plasma is 0.00004 mmol/L.This is usually expressed as pH, which is a negative logarithm.A H
+
conc of 0.0004 mmol/L is equal to a pH of 7.4.pH equivalent to – log
10
[H
+
]A change in pH from 7.4 to 6.4 e.g. represents a 10-fold increase in [H
+
]When pH is below 7.4 , acidosis is present, and whenpH is above 7.4 alkalosis is present.
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