Inhibits bacterial protein
synthesis at the level of the 30S
Low-dose products used in the
management of periodontitis
Treatment of various infections
caused by unusual organisms,
May cause yellow-brown discoloration and softening of teeth
and bones if administered prenatally or during early
childhood. Not recommended for children under 8 yr of age or
during pregnancy or lactation, unless used for the treatment of
meals. May be taken with food or milk if GI irritation occurs.
Administer with a full glass of liquid and at least 1 hr before going
to bed to avoid esophageal ulceration. Use calibrated measuring
device for liquid preparations. Shake liquid preparations well. Do
not administer within 1\u20133 hr of other medications.
Avoid administration of calcium, antacids, magnesium-
containing medications, sodium bicarbonate, or iron
supplements within 1\u20133 hr of oral doxycycline.
Avoid taking antacids, calcium, magnesium-containing
medications, sodium bicarbonate, and iron supplements within 1\u20133
hr of oral doxycycline.
Report the signs of superinfection (black, furry overgrowth on the tongue, vaginal itching or discharge, loose or foul-smelling stools). Skin rash, pruritus, and urticaria should also be reported.
Treatment of inhalational anthrax
(postexposure) and cutaneous
Treatment of gonorrhea and
syphilis in penicillin-allergic
Pharmacologic: , hormones
Monitor blood pressure before and throughout therapy. Inform
physician or other health care professional if severe hypertension
is present or if blood pressure begins to increase. Additional
antihypertensive therapy may be required during initiation of
Monitor dialysis shunts (thrill and bruit) and status of artificial
kidney during hemodialysis. Heparin dose may need to be
increased to prevent clotting.
Serum ferritin, transferrin, and iron levels should also be
monitored to assess need for concurrent iron therapy.
Transferrin saturation should be at least 20% and ferritin
should be at least 100 ng/ml.
Institute seizure precautions in patients who experience
greater than a 4-point increase in hematocrit in a 2-wk period
or exhibit any change in neurologic status. Risk of seizures is
greatest during the first 90 days of therapy.
Discard vial immediately after withdrawing dose from single-
use 1-ml vial. Refrigerate multidose 2-ml vial; stable for 21
days after initial entry.
May be admixed in syringe immediately before administration
with 0.9% NaCl with benzyl alcohol 0.9% in a 1:1 ratio to
prevent injection site discomfort.
Discuss possible return of menses and fertility in women of
childbearing age. Patient should discuss contraceptive options
with health care professional.
Discuss ways of preventing self-injury in patients at risk for
seizures. Driving and activities requiring continuous alertness
should be avoided.
Pharmacologic:e s t ro g e n s
Estrogens promote growth and
development of female sex
organs and the maintenance of
changes , anorexia,
cervical erosions, loss of
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