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Monoclonal

Monoclonal

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Published by doctorrao
The development of Hybridoma technology proved a boon to clinical medicine with advances in diagnostic and therapeutic options in cure and early diagnosis of several medical conditions
The development of Hybridoma technology proved a boon to clinical medicine with advances in diagnostic and therapeutic options in cure and early diagnosis of several medical conditions

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Published by: doctorrao on Apr 19, 2009
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04/13/2014

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MONOCLONALMONOCLONAL
 
antibodiesantibodies
 
Dr.T.V.Rao MDDr.T.V.Rao MD
 
 
Beginning of Monoclonal EraBeginning of Monoclonal Era
Georg KohlerGeorg Kohler
andand
Cesar MilsteinCesar Milstein
 fuse mouse lymphocytes withfuse mouse lymphocytes withneoplastic mouse plasma cells toneoplastic mouse plasma cells toyield hybridomas that produceyield hybridomas that producespecific antibodies. This offers aspecific antibodies. This offers alimitless supply of monoclonallimitless supply of monoclonalantibodies. Monoclonal antibodiesantibodies. Monoclonal antibodiespermit diagnostic tests that arepermit diagnostic tests that arespecific, and function as probes.specific, and function as probes.
 
 
Discovery of MonoclonalDiscovery of MonoclonalAntibodiesAntibodies
MonoclonalMonoclonalantibodies wereantibodies wereproduced in miceproduced in miceusing a techniqueusing a techniquedescribed bydescribed by
Köhler andKöhler andMilstein et al..Milstein et al..
  They were awarded They were awardedthethe
Nobel Prize inNobel Prize in1984 (along with1984 (along with Jerne) for their Jerne) for theirwork.work.

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