Mobile and cordless telephones, serum transthyretin and the blood-cerebrospinal fluid barrier

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Mobile and cordless telephones, serum transthyretin and theblood-cerebrospinal fluid barrier: a cross-sectional study

Environmental Health

2009,

8

:19 doi:10.1186/1476-069X-8-19Fredrik Soderqvist (fredrik.soderqvist@orebroll.se)Michael Carlberg (michael.carlberg@orebroll.se)Lennart Hardell (lennart.hardell@orebroll.se)

ISSN

1476-069X

Article type

Research

Submission date

11 February 2009

Acceptance date

21 April 2009

Publication date

21 April 2009

Article URL

http://www.ehjournal.net/content/8/1/19This peer-reviewed article was published immediately upon acceptance. It can be downloaded,printed and distributed freely for any purposes (see copyright notice below).Articles in

Environmental Health

are listed in PubMed and archived at PubMed Central.For information about publishing your research in

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Environmental Health

et al.

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

Mobileandcordlesstelephones,serumtransthyretinandtheblood-cerebrospinalfluidbarrier:across-sectionalstudy

FredrikSöderqvist

1,2§

,MichaelCarlberg

1

,



LennartHardell

11

DepartmentofOncology,UniversityHospital,SE-70185Örebro,Sweden

2

SchoolofHealthandMedicalSciences,UniversityofÖrebro,SE-70182Örebro,Sweden.

§

CorrespondingauthorEmailaddresses:

FS

fredrik.soderqvist@orebroll.se

MC

michael.carlberg@orebroll.se

LH

lennart.hardell@orebroll.se



Abstract

Background:



Whetherlow-intensityradiofrequencyradiationdamagestheblood-brainbarrierhaslongbeendebated,butlittleornoconsiderationhasbeengiventotheblood-cerebrospinalfluidbarrier.Inthiscross-sectionalstudywetestedwhetherlong-termand/orshort-termuseofwirelesstelephoneswasassociatedwithchangesintheserumtransthyretinlevel,indicatingalteredtransthyretinconcentrationinthecerebrospinalfluid,possiblyreflectinganeffectofradiation.

Methods:



Onethousandsubjects,500ofeachsexaged18-65years,wererandomlyrecruitedusingthepopulationregistry.DataonwirelesstelephoneusewereassessedbyapostalquestionnaireandbloodsampleswereanalyzedforserumtransthyretinconcentrationsdeterminedbystandardimmunonephelometrictechniquesonaBNProspec

®

instrument.

Results:

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Theresponseratewas31.4%.LogisticregressionofdichotomizedTTRserumlevelswithacut-pointof0.31g/lonwirelesstelephoneuseyieldedincreasedoddsratiosthatwerestatisticallynotsignificant.Linearregressionoftimesincefirstuseoverallandonthedaythatbloodwaswithdrawngavedifferentresultsformalesandfemales:formensignificantlyhigherserumconcentrationsofTTRwereseenthelongerananaloguetelephoneoramobileandcordlessdesktoptelephonecombinedhadbeenused,andincontrast,significantlylowerserumlevelswereseenthelongeranUMTStelephonehadbeenused.AdjustmentforfractionsofuseofthedifferenttelephonetypesdidnotmodifytheeffectforcumulativeuseoryearssincefirstuseformobiletelephoneandDECT,combined.Forwomen,linearregressiongaveasignificantassociationforshort-termuseofmobileandcordlesstelephonescombined,indicatingthatthesoonerbloodwaswithdrawnafterthemostrecenttelephonecall,thehighertheexpectedtransthyretinconcentration.

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Conclusions:

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Inthishypothesis-generatingdescriptivestudytimesincefirstuseofmobiletelephonesandDECTcombinedwassignificantlyassociatedwithhigherTTRlevels