Welcome to Scribd, the world's digital library. Read, publish, and share books and documents. See more
Buy Now $192.00
Standard view
Full view
of .
Look up keyword or section
Like this
3Activity

Table Of Contents

TOXICOINFORMATICS: AN INTRODUCTION
CURRENT QSAR TECHNIQUES FOR TOXICOLOGY
THE PREDICTION OF PHYSICOCHEMICAL PROPERTIES
APPLICATIONS OF QSAR TO ENZYMES INVOLVED IN TOXICOLOGY
QSAR STUDIES ON DRUG TRANSPORTERS INVOLVED IN TOXICOLOGY
COMPUTATIONAL MODELING OF RECEPTOR-MEDIATED TOXICITY
APPLICATIONS OF QSAR METHODS TO ION CHANNELS
PREDICTIVE MUTAGENICITY COMPUTER MODELS
HOMOLOGY MODELS APPLIED TO TOXICOLOGY
CRYSTAL STRUCTURES OF TOXICOLOGY TARGETS
EXPERT SYSTEMS
APPLICATION OF INTERPRETABLE MODELS TO ADME/TOX PROBLEMS
THE TOXICITY AND RISK OF CHEMICAL MIXTURES
APPLICATION OF QSARs IN AQUATIC TOXICOLOGY
DERMATOTOXICOLOGY: COMPUTATIONAL RISK ASSESSMENT
COMPUTATIONAL TOOLS FOR REGULATORY NEEDS
INDEX
P. 1
Computational Toxicology: Risk Assessment for Pharmaceutical and Environmental Chemicals

Computational Toxicology: Risk Assessment for Pharmaceutical and Environmental Chemicals

Ratings: (0)|Views: 78|Likes:
Published by Wiley
A comprehensive analysis of state-of-the-art molecular modeling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals

This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with:
*

An introduction to toxicology methods and an explanation of computational methods
*

In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels
*

Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena
*

Chapters written by leading international experts
*

Figures that illustrate computational models and references for further information

This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development.
A comprehensive analysis of state-of-the-art molecular modeling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals

This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with:
*

An introduction to toxicology methods and an explanation of computational methods
*

In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels
*

Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena
*

Chapters written by leading international experts
*

Figures that illustrate computational models and references for further information

This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development.

More info:

Publish date: Jul 27, 2007
Added to Scribd: Jun 03, 2013
Copyright:Traditional Copyright: All rights reservedISBN:9780470145883
List Price: $192.00 Buy Now

Availability:

Read on Scribd mobile: iPhone, iPad and Android.
This book can be read on up to 6 mobile devices.
See more
See less

03/02/2015

855

9780470145883

$192.00

USD

You're Reading a Free Preview
Pages 18 to 154 are not shown in this preview.
You're Reading a Free Preview
Pages 172 to 598 are not shown in this preview.
You're Reading a Free Preview
Pages 616 to 652 are not shown in this preview.
You're Reading a Free Preview
Pages 670 to 725 are not shown in this preview.
You're Reading a Free Preview
Pages 743 to 855 are not shown in this preview.

Activity (3)

You've already reviewed this. Edit your review.
1 thousand reads
1 hundred reads

You're Reading a Free Preview

Download
scribd