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Congressional Research Service 
 
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The Library of Congress 
CRS Report for Congress
Received through the CRS Web
Order Code RL33145
Pandemic Influenza:Domestic Preparedness Efforts
November 10, 2005
Sarah A. ListerSpecialist in Public Health and EpidemiologyDomestic Social Policy Division
 
Pandemic Influenza: Domestic Preparedness Efforts
Summary
In 1997, a new avian influenza virus (H5N1 avian flu) emerged in Hong Kong,killing six people. This was the first time that an avian influenza virus was shownto be transmitted directly from birds to humans. The virus persisted in the region,and has since spread to a number of Asian and European countries, where it hasinfected more than 120 people, killing more than 60. The severity of this strain issimilar to that of the deadly 1918 Spanish flu, which caused a global pandemic thatmay have killed up to 2% of the world’s population. Though influenza pandemicsoccur with some regularity, and the United States has been involved in specificplanning efforts since the early 1990s, the H5N1 situation has created a sense of urgency among the world’s public health officials.Global pandemic preparedness and response efforts are coordinated by theWorld Health Organization (WHO). The U.S. Department of Health and HumanServices (HHS) released a draft pandemic flu preparedness and response plan inAugust 2004, and a final plan in November 2005. President Bush announced anational strategy to coordinate pandemic preparedness and response activities acrossfederal agencies. Domestic response activities will be carried out under the broad,all-hazards blueprint for a coordinated federal, state and local response laid out in theNational Response Plan, released by the Department of Homeland Security (DHS)in 2004.Even in light of the plans discussed above, if a flu pandemic were to occur inthe next several years, the U.S. response would be affected by the limited availabilityof a vaccine (the best preventive measure for flu), as well as by limited availabilityof certain drugs used to treat severe flu infections, and by the general lack of surgecapacity within our healthcare system. The U.S. healthcare system is largely private,while the public health system is largely based in state, rather than federal, authority.This structure creates numerous challenges in assuring the needed response capacity,and coordinating the various response elements. Planning is further complicated bythe fact that while periodic influenza pandemics have been seen over the years, theirtiming and severity have been unpredictable. This report will be updated to reflectchanging circumstances.
 
Contents
Introduction......................................................1Understanding Pandemic Influenza....................................3What Is Pandemic Influenza?....................................3Pandemic Phases..............................................4Influenza Pandemics in the 20
th
Century............................6Current Situation..............................................7H5N1 Avian Influenza......................................7Other Flu Strains with Pandemic Potential......................8Potential Impacts of an Influenza Pandemic.........................9Deaths and Hospitalizations..................................9Economic Impacts........................................11Pandemic Influenza Preparedness and Response.........................11WHO Global Influenza Preparedness Plan.........................12HHS Draft Pandemic Plan......................................12National Strategy for Pandemic Influenza..........................13HHS Final Pandemic Plan......................................14Department of Defense Planning and Activities.....................14Department of Veterans Affairs Planning and Activities..............15State Pandemic Preparedness Plans...............................15Issues in Pandemic Influenza Planning................................16Could an Influenza Pandemic Be Stopped?.........................16Whos in Charge?............................................17Emergency Declarations and Federal Assistance.....................19Limited Surveillance and Detection Capability......................20Isolation and Quarantine.......................................21Rationing Scarce Resources.....................................23Influenza Vaccine Supply and Use...............................25Limited Vaccine Production Capacity.........................25Regulatory Issues.........................................26Liability and Compensation.................................27Intellectual Property Issues.................................29Antiviral Drug Supply and Use..................................30Influenza as a Weapon.........................................32
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