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smooth muscle cell receptordrug action bind to receptor
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smooth muscle receptor activated----increase in permeability to K+
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effect –decerase membrane potential
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increase excitability of uterine smooth muscle
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effect coordinated , regular uterine
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Action on gravid uterus and breast milk ductClinical useAugmentation of labour
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Used in obstetric to cause uterine constriction
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Uterine constriction ---as induction of labourPost-partum
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Uterine contraction post-delivery
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Also to prevent PPHLactation
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To induce lactationDose and administration
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Onset – 30 sec- 1 minutes – IV, 2 minutes - Im
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Duration of action – 3-5 minutes IV, IM – 60 minutesPharmacokineticAbsorbtion
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Poor oral bioavailibility
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Reason; inactivation by chymotripsin as a first pass effect
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Has to be administered parentally
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Also can be given, intranasalPharmacodynamicCVSHR
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Tachycardia ---then hypotension ---non-specific ST changesSVR
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Causes vasodilation ---manifestated as flushing
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Vasodilation ---decrease SVR---hypotensionBP
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Hypotension ----initiate baroceptor reflex
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Baroreceptor reflex ---reflex tachycardia---net increase in cardiac output
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Anesthetic implication ---further aggravate hypotension produced by concurrentanesthetic agent
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