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SAQ 1. Describe renal compensation in acid base balance
Outline:
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IntroductionWhat is acidosis (define)Response to acidosis in general-buffering-compensation-correctionRole of kidney in compensation for acidosisRestoration of [HCO3]/PaCO2 ratio
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Compensatory mechanisms1.secretion of hydrogen ions associated with HCO3- reabsorption- at proximal tubules,thick ascending limb, early distal tubulespercent?low gradient, high capacity system – means?(diagram)secondary active Na/H countertransport mechanismenergy derived by Na/K –ATPase (basolateral membrane)CARatio of H to HCO3-late distal tubules ,collecting ductspercent?Primary active intercalated cellsH-ATPase transport(diagram)Ratio of H to HCO3High gradient low capacity system - means?H secretion in distal tubules is controlled by aldosteroneImportance2.excretion of titratable aciditydefineimportant buffer systems involved(diagram)ratio
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