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Table Of Contents

Acknowledgments
Handedness
The Symmetry of Nonsuperimposable Mirror Images
Nomenclature for Chiral Molecules
Nomenclature for Dissymmetric and Other Chiral Molecules
Summary
Suggestions for Further Reading
References
List of Biographic Photographs, Sidebars, and Figures
Optical Rotation
From Biot to Pasteur
Biochemical Homochirality
Determination of Absolute Structures of Chiral Molecules
Must Life Be Chiral?
Mirror-image life?
The Origin of Homochirality in Living Systems
Extraterrestrial Chirality
Nuclear Chirality
Other Extraterrestrial Sources
The Beginning of Life on Earth: Biochemistry
Getting Started in the Right (or Left) Direction
Suggestions For Further Reading
List of Sidebars and Figures
Chiral Chemical Evolution
Chiral Recognition at the Molecular Level
Examples of Chiral Recognition and Discrimination
Chirality as a Control Mechanism in Biochemistry
Chirality in Natural Remedies and Folk Medicines
Enantiomeric Differences in Natural Products
Thalidomide and Regulation of Chiral Drugs
Chirality and Drug Activity
Chiral Switching
Ephedrine, Pseudoephedrine, and Methamphetamine
Preparation of Pure Enantiomers
Preliminary Cautions
Chirality In Nature
Classification of Plant and Animal Chirality (Asymmetry)
Homo sapiens Asymmetry
Are You Right-Handed or Left-Handed?
The Statistics of Handedness
The Origin of Left-Handedness
The Human Genetics of Handedness
Clockwise and Counterclockwise (or Anticlockwise) Rotation
Helical Stairways
Around the House
Making Music Left-Handed
The Chirality of Writing
Sports and the Left-Hander
American Baseball: The Chiral Sport
Driving on the Left or Right Side
Windmills
List of Figures
P. 1
Mirror-Image Asymmetry: An Introduction to the Origin and Consequences of Chirality

Mirror-Image Asymmetry: An Introduction to the Origin and Consequences of Chirality

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Published by Wiley
An overview of the importance and consequences of asymmetry from molecules to the macroscopic world

As scientists have become more capable of probing the structure of three-dimensional objects at the molecular level, the need to understand the concept and the consequences of mirror-image asymmetry—chirality—has increased enormously. Written at an introductory level, Mirror-Image Asymmetry provides an overview of the importance and effects of asymmetry from the atomic and molecular world of physics and chemistry to the organisms and structures that we see and use in our everyday life. The reader will develop a broad appreciation of three-dimensional asymmetry from the microscopic molecular world to the macroscopic world of handedness, automobile driving, windmills, sports, and similar phenomena. The book features:

An introduction to basic definitions and the nomenclature of asymmetric and dissymmetric molecules

Up-to-date examples of the importance and consequences of asymmetry in modern drug applications, current theories of the origin of asymmetry in nature, and examples of molecular asymmetry in smell, taste, and insect communication

Many illustrations, chemical structures, and photographs that enable the reader to connect the actual asymmetrical structures to the different phenomena that depend on structural asymmetry

In the 150 years since Louis Pasteur discovered asymmetry in molecular structures, scientists have made great progress in understanding how interactions between chiral molecules influence biochemical processes. This knowledge is leading to very sophisticated asymmetric synthetic techniques that have greatly benefitted many research groups especially those in the pharmaceutical industry. This guide to the role of molecular and macroscopic chirality will inspire students and scientists in chemistry, biology, physics, and drug discovery.

An overview of the importance and consequences of asymmetry from molecules to the macroscopic world

As scientists have become more capable of probing the structure of three-dimensional objects at the molecular level, the need to understand the concept and the consequences of mirror-image asymmetry—chirality—has increased enormously. Written at an introductory level, Mirror-Image Asymmetry provides an overview of the importance and effects of asymmetry from the atomic and molecular world of physics and chemistry to the organisms and structures that we see and use in our everyday life. The reader will develop a broad appreciation of three-dimensional asymmetry from the microscopic molecular world to the macroscopic world of handedness, automobile driving, windmills, sports, and similar phenomena. The book features:

An introduction to basic definitions and the nomenclature of asymmetric and dissymmetric molecules

Up-to-date examples of the importance and consequences of asymmetry in modern drug applications, current theories of the origin of asymmetry in nature, and examples of molecular asymmetry in smell, taste, and insect communication

Many illustrations, chemical structures, and photographs that enable the reader to connect the actual asymmetrical structures to the different phenomena that depend on structural asymmetry

In the 150 years since Louis Pasteur discovered asymmetry in molecular structures, scientists have made great progress in understanding how interactions between chiral molecules influence biochemical processes. This knowledge is leading to very sophisticated asymmetric synthetic techniques that have greatly benefitted many research groups especially those in the pharmaceutical industry. This guide to the role of molecular and macroscopic chirality will inspire students and scientists in chemistry, biology, physics, and drug discovery.

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Publish date: Apr 22, 2011
Added to Scribd: Jun 12, 2013
Copyright:Traditional Copyright: All rights reservedISBN:9780470588871
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