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How to turn the « Charmr » Concept into Reality ?
 The only compatible long-term storage material for insulin is a recipient made of a glass such as vials and penfillcartridges. Another condition includes the fact that the pump should have a sterile means to deliver the insulin at a lowcost. The only solution available on the market is a small disposable syringe made of plastic that has to be filledmanually by the patient by transferring the insulin from the vial to the disposable syringe. This is the procedure thatpatients have to perform several times a week when using their insulin pump or patch.
This handling exercise ishowever rather difficult for many patients because of the fragile nature of the insulin. The use of syringe is alsopretty complicated for disabled persons or persons with limited mobility, for children and ageing persons. 
Limitations
An insulin pump should deliver an exact and precisequantity of insulin in a form of liquid by perfusion.
 Thepump should possess a compatible insulin reservoir for itsstorage during the delivery. The other possibility is to use an insulin penfill cartridge made of glass as a tank for the insulin pump. Until recently, there is apossibility to integrate the system of insulin pen delivery into thepump system. However, this system cannot ensure the requiredprecision for a pump because when pushing directly the cap of thepenfill cartridge, the friction is too important, irregular anduncontrolled due to the phenomenon known as a “stick slip” effect. The alternative pumping system such as the peristaltic pump doesnot give enough precision and the MEMS technology cannotaspirate the penfill cartridge.Many patients using insulin pumps have askedmanufacturers to innovate and to improve the currentlyavailable devices on the market to make their use easierand simple with a smaller size and light weight, like a cellphone for example.
 All rights reserved – Copyrights – Patent Pending Technology 
Direct Penfill LoadingDisposable Loading
 The «
Charmr
» concept is the most strikingexample. However, likewise many ideas, thepassageway from conceptual idea into concreteproduct cannot overcome the barriers of technical and industrial feasibility. To validate aconcept and its feasibility, there is a need toconsider the real limitations of an insulin pump.By looking at the constraints related to an insulinpump, it becomes obvious that many ideas willnever be brought to life as they cannot beapplied to this field.
Introduction
Medicine today relies on provenand tested technologies to ensurethe efficiency of medical devices. Treating diabetes with an insulinpump requires as much as rigorousprecautions than any other medicaldevices because of the pump itself is
a vital element placed at thehand of the patients.
 
Only
2oz
with a penfillcartridge of 
3ml
(300U)
 
 
Today such a
revolutionarysolution
 
exists
; here is the
« PicoSulin »
 
PicoSulin
has far exceeded the stage of concept andideas and certainly is the solution for thousands of patients waiting for an easier handling of their diabetes.
PicoSulin
is a truly technology breakthrough offeringnew perspectives for treatment, easy to use in a verysmall and compact size.
PicoSulin paves the way for new therapies by allowingfor the first time the delivery of small nano-boluswhich imitates the natural secretion of insulin by thepancreas; the delivery is also possible in a closed loopsystem with an integrated glucose sensor.
The ideal solution
The solution is to have an ultra small and very light pump using a technology that is capable of infusing the insulin directly from a penfill cartridge without manipulating the insulin and this newpump will have a better precision and a lower cost that a syringe.
 The insulin pump should also consider all the conditions for its daily use such as the availability of a battery everywhereat anytime, the resistance to impacts, the sealing, the user friendly, the light weight, the communication with a PC, theconnexion to a glucose sensor and all of this wrapped up in a small device ideally with the same dimensions as a box of matches.It is therefore fairly obvious that putting together all of those elements into a micro medical device requires lots of investments, lab developments, testing by manufacturers and the patience of the patients.
What
is the
secret
of 
« PicoSulin »
?
PicoSulin
is the result of several years of research and developments in the field of micro liquid delivery. Thesimplicity of the system is based on the use of 
plastic micro pump which is connected to an ultra precisemechanical system (patent pending)
capable to deliver a
bolus of 25nl
(0.0025U) that is 20 times more precisethan any other pump on the market which delivers 500nl (0.05U).Moreover, this micro pump uses a principle of 
volumetric pump capable to aspirate the insulin directly fromany type or brand of penfill cartridge
. Its major advantages beyond its performances are its very small size and itsmodularity that gives the
« PicoPump »
a portable pump, 50% much smaller than one of the smallest pump on themarket such as the Animas 2020 and a patch, 20% smaller than OmniPod. The
« PicoPatch »
differs from theOmniPod by having only one disposable plastic element which is an environmentally friendly solution.
How to turn the « Charmr » Concept into Reality ?
 
 All rights reserved – Copyrights – Patent Pending Technology 
Ultra small
0.58” x 1.46” x 2.5” (2.83”)
of 00

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