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Carbohydrate-Based Vaccines and Immunotherapies
By Zhongwu Guo and Geert-Jan Boons
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About this ebook
The fundamental science and the latest developments in carbohydrate-based vaccines
The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments.
With contributions by leading experts, this resource covers the design, synthesis, evaluation, and applications of various carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids. The text approaches vaccine design from a chemical and molecular focus, staying in line with current advances.
Key topics covered by Carbohydrate-Based Vaccines and Immunotherapies include:
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Recent developments towards clinically useful vaccines against bacteria, viruses, parasites, and fungi
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Using adjuvants to improve immunogenicity and/or immunological properties of vaccines
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Choosing and designing proper adjuvants for specific targets
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Abnormal carbohydrates expressed by tumors
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Carbohydrate-based therapeutic cancer vaccines or cancer immunotherapy
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Clinical trials results for synthetic cancer vaccines
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Glycoengineering of cell surface carborhydrates and its anticancer applications
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Using cell surface carbohydrates for disease diagnosis
A single, convenient source of state-of-the-art information from leading authorities in the field, Carbohydrate-Based Vaccines and Immunotherapies is an essential reference for organic chemists and biochemists, academic researchers, and other students and professionals involved in vaccine design.
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