Professional Documents
Culture Documents
H A .
.
, ,
.
(acetylsalicylic acid, ASA),
(aspirin),
40.000
3600 100 mg.
16.000 .
. 23
.
1899, Aspirin. "a"
acetyl () "spir" Spiraea ulmaria,
(
Spirsure) "in",
.
.
. 30-40
, 15-20 , .
2 (TXA2) ,
.
. - ,
, ,
.
.
. , ,
.
.
. ,
, , ,
HDL , ,
( ) ,
.
,
,
.
, .
.
-
.
Sex
Male
Female
Choresterol
mg/dl
HDL-Chol
mg/dl
Blood pressure
Optimal (SBP<120)/(DBP<80)
Diabetes
No
Smoking
No
No ulcer history
NSAID use
No
CV Treatment
ASA
Yes
Clopidogrel
No
Warfarin
No
Calculate
,
.
:
1. European Guidelines on cardiovascular disease prevention in clinical practice
(version 2012)
2. Guidelines of ACCF/AHA 2009 Performance Measures for Primary Prevention
of Cardiovascular Disease in Adults
3. Michael S.Lauer, M.D. Aspirin for primary prevention of coronary events. N
Engl J Med, 2002; 346: 1468 -1474
4. Karha, J., Rajagopal, V., Kottke-Marchant, K., Bhatt, D.L. Lack of effect of
enteric coating on aspirin-induced inhibition of platelet aggregation in
healthy volunteers. Am Heart J 2006, 151: 976. e7-11
5. Aspirin for primary prevention of cardiovascular disease events. Nemerovski
CW, Salinitri FD, Morbitzer KA, Moser LR. Pharmacotherapy. 2012 Nov;
32(11):1020-35.
6. Aspirin in the primary and secondary prevention of vascular disease:
collaborative meta-analysis of individual participant data from randomised
trials. Antithrombotic Trialists' (ATT) Collaboration, Baigent C, Blackwell L,
Collins R, Emberson J, Godwin J, Peto R, Buring J, Hennekens C, Kearney P, et
al. Lancet. 2009 May 30; 373(9678):1849-60
7. Aspirin treatment failure: is this a real phenomenon? A review of the
aetiology and how to treat it. Shahid F, Chahal CA, Akhtar MJ. JRSM Short
Rep. 2013 Apr; 4(4):30. Epub 2013 Mar 27