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THE MALIGNANT COUPLE:THE MALIGNANT COUPLE:PHENACETINPHENACETINNEPHROPATHY-NEPHROPATHY-UROTHELIAL TUMORSUROTHELIAL TUMORS
Scientific coordinatorsScientific coordinators
::MITITIUC IRINA,PhDMITITIUC IRINA,PhDHOGAS SIMONA,MDHOGAS SIMONA,MD
AuthorAuthor
: Pricop Mariana: Pricop Mariana
CoauthorsCoauthors
: Pricop Daniela: Pricop DanielaBiru DianaBiru Diana-Madalina-Madalina
 
PHENACETINPHENACETIN
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Phenacetin, introduced in1887, was used principallyas an analgesic, and wasone of the first syntheticfever reducers to go on themarket.
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It is also knownhistorically to be the firstanalgesic without anti-inflammatory properties.
 
PHENACETINPHENACETIN
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Phenacetin was widely used until the third quarter of the twentieth century, but was then largely replacedby non-carcinogenic drugs. 
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Some branded phenacetin-based preparationscontinued to be sold, but with the phenacetinreplaced by safer alternatives.
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A popular brand of phenacetin was Roche's Saridon,which was reformulated in 1983 to containpropyphenazone, paracetamol and caffeine.
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Paracetamol is a metabolite of phenacetin withsimilar analgesic and antipyretic effects, but the newformulation has not been found to have phenacetin'scarcinoenicit.
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