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A quick reference guide tohaemofiltration and renal failureMarch 2004Alison Bradshaw
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Page 3…
Acute Renal Failure
Page 4…
Normal Kidney Function
Page 5…
Nephron Function
Page 6…
Definitions of Key Words
Page 7…
Indications for CRRT 
Page 8… TYPES OF CRRT 
SCUF
Page 9…
CVVHF
Page 10…
Predilution or Postdilution?
Page 11…
CVVHD
Page 12…
CVVHDF
Page 13…
Transport of molecules
 Page 14… PRINCIPLES OF DIALYSIS
Diffusion
Page15…
Filtration
Page 17.
.. Convection
Page 18
Application of Principles
 Page 19
Manipulation of PrinciplesSummary of Principles
Page 21
VASCULAR ACCESS
 
Page 22
Dos and Don’ts of Vascular Access
Page 23
ANTICOAGULATION
 
Page 24
The Clotting Cascade
Page 25
… Heparin
Page 26
Regional Heparinization and Citrate
Page 27
Saline Flushes and Table of Anticoagulant Options
Page 28… THE HAEMOFILTERPage 30… DIALYSATE COMPOSITIONPage 32… CARE OF THE PATIENT Page 36… NUTRITIONPage 37… CARE OF THE MACHINEPage 38…
The BM 25
Page 39…
The Aquarius
Page 40…
Guide to Troubleshooting Alarms – The Aquarius
Page 41… References
 
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Acute renal failure (ARF) is a common complication of thecritically ill patient. Types of ARF include;
PRERENAL FAILUREINTRARENAL FAILUREPOSTRENAL FAILUREPrerenal failure; 
this is the most common type of ARF. It is aresult of renal ischaemia caused by a significant decline in renalblood flow. Decline in renal blood flow and a fall in glomerularfiltration rate may result from hypovolaemia, a decrease incardiac output or sepsis.
(Dirkes,2000:581)
 
Intrarenal Failure; 
indicates injury to the nephrons within thekidney itself, usually caused by nephrotoxins. Some of thesepotential nephrotoxins are aminoglycosides, heavy metals,contrast dye. Prolonged ischaemia in the kidney will causeintrarenal failure as well.
(Dirkes, 2000:581)
 
Postrenal Failure; 
occurs when here is an obstruction to the outflow of urine from the kidney. Urinary tract obstruction,including renal stones, tumors and prostatic hypertrophy arecommon causal factors.
(Dirkes, 2000:581)
 
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