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Results of DMSA Treatment Study

James Adams, Liz Geis, Matthew Baral, Jessica
Mitchell, Julie Ingram, Andrea Hensley,
Sanford Newmark, Eva Gehn, Bob Rubin,
Warren Tripp, Ken Mitchell, Jeff Bradstreet,
Jane El-Dahr

Southwest College of Naturopathic Medicine
Funded by Wallace Foundation and
Autism Research Institute
Current study
Goal: Determine if DMSA/glutathione therapy helps
children with autism.

Phase 1: 9 doses of DMSA over 3 days, 10 mg/kg- dose; collect urine at baseline, after 1st dose, and after 9th dose; daily doses of \u201cglutathione\u201d

- if high toxic metal excretion, continue to phase 2
Phase 2: 3 month, double-blind, 1 round-controlled
treatment study;
3 days on DMSA, 11 days off; repeat 6x

82 children enrolled
65 completed phase 1
41 completed phase 2

Phase 1

\u2022Started with 82 participants
\u20221 did not qualify due to elevated liver enzymes
\u20224 stopped after physical exam
\u202211 stopped after initial blood draw (2 could not

collect baseline urine)
\u20221 collected urine after DMSA but did not send to
lab (busy family)
\u202265 collected urine after DMSA and sent to lab for
testing
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