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Workshop 20

Workshop 20

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Published by Mohammad_Islam87

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Published by: Mohammad_Islam87 on May 10, 2009
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02/01/2013

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Workshop
nr 20
- RenalPathologY
II
Topic
MICROSCOPY-MI
I.
Tubulo-interstitial
NP
1.
Toxic
tubulonecrosis
2.
Actte
suppurativePN
II.
RenalTumors
1.
Grawitz
Tumors
2.
Wilms
Tumors
MACROSCOPY.MA
I.
Tubulo-interstitial
NP
1.
Toxictubulonecrosis
2.
Acute
suPPurative
PN
II.
Renal tumors
.
Grcwitz
Tumors
.
Wilms
Tumors
.
Secondarvcancer(metastasis)MICROSCOPY-MI
I.Tubular
and
interstitial
diseases
l.Toxic
tubulonecrosis-
acute
tubular
necrosis
-
tubularepithelial
necrosis
)
is manifested
clinically
by
acute
renal
failure
(ARF)-
causes:
toxic
or
ischemic-
toxictubular
necrosis
-nephrotoxic
substances:exogenous:
heavymetals
(Pb,
Hg),
organicsolvents
(CCl4),
drugs
(Ab,
NSAIDs)
MI
e
toxic
acute
tubulonecrosis-thelesions
are
located
in
proximal
epithelial
tubules
)tubular
epithelial
necrosis
o
necrotic
epithelial
cells
have
uniform
appearance,
acidophilic,
without
nuclei,
somedetacheand
fall
in
the
lumen(epithelial cylinders
or
casts).
o
tubular
BM
isintact,forming
thesupport
for
epithelialremainingcell
regeneration
.
normalglomeruli
2.Inflammatory
lesions
-Pyelonephritis
(PN)
)
acute
suppurativePN
o
inflammatory
renal
disease
of
bacterial
etiology
)
affecting
tubules,
interstitium
and
renal
pelvis
o
EtioloBy:
gram negativeaffect
kidney
on2
waYs:
bacteria
G.
coli,
less
Proteus
and
Pseudomonas)
)they
-
by
ascending
way:
bladder
infection
is
ascending
tofavored
byobstructive
lesions
of UT
-calculi,
tumorsthe
kidneyinfection
is
-
by
descending
way:kidneyinfection
occurs
in
septicemia
MI
.
interstitial
microabscesses
containing
occasional
microbial
colonies
.
tubular
necrosis
.
PMNsform
leuco
citary
casts
or
cylindersin
renaltubules
.
slomeruli
are
normal

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