the work done in yeast-cell suspensions was that a deconvolution of the compartmentaleffects could provide valuable information on the behavior of water. With this goal inmind, a majority of my research efforts was devoted to investigating model systems forunderstanding the diffusion behavior of water in a two-compartment system. Fortunately,a well-characterized system was available in yeast-cell suspensions. The yeastexperiments should serve merely as a stepping stone to other experiments which furthercharacterize the model system and, ultimately, carry over to
experiments tounderstand the behavior of water during ischemic brain injury.The last experiment in this dissertation deals with diffusion of water in excised rabbitAchilles tendon. The initial set of experiments on tendon gave very promising results andeventually led to a Master’s thesis for one of my colleagues. Unfortunately, furtherinvestigation into the behavior of the tendon revealed that these observed effects were nomore than an artifact of the storage medium. The initial discovery of this fact wasdisappointing, but at the same time opened up another avenue for the direction of theseexperiments. In wrestling with the logistics of measuring NMR properties of tendons,most of the groundwork has been laid for future studies. Although these results are notcompletely revealing, we are still of the belief that the viscoelastic properties of tendonschange with tensile load. Whether this phenomenon is observable
NMR is still to bedetermined.