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My Op at Hies

My Op at Hies

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Published by: bpt2 on May 13, 2009
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04/08/2014

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Myopathies
Dr. Ghaith J. Al-Eyd M.B.Ch.B., M.Sc., Ph.D.
GMC / Department of Pathology
2
nd 
BPT 
 
 
Reaction of Muscle Cells to Injury:
Atrophy; occurs with disuse, ischemia & denervation.
Hypertrophy; in response to increased load, or to c
ompensate
 for loss.
Necrosisof muscle fiber.
Phagocytosisof dead muscle fibers by macrophages.
Regenerationtakes place from the population of stem cells(satellite cells).
Fatty infiltration&Fibrosis.
Primary inflammation.
 
 
Muscle Diseases (Sign & Symptoms):
Clinical manifestations:
Progressive muscle weakness.
Muscle wasting.
Stiffness or myotonia.
Fasciculation
(abnormal involuntary contractions giving a twitching  sensation).
Cramping, aching, tenderness.
Easy fatigability.

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