Background : Coronary heart disease one of them is atherosclerosis it is main cause dead in the world, from epidemical study

get that in year of 2002 there are 117 million people was died because it, and predictable in 2020 increase to 11 million. Extract from pericap of mangosteen have the active compound it is call xanthone, from the last experiment has known that xanthone have antioxidant activity , its can inhibit realease of free radical as the patoghenesis of atherosclerosis so its can prevent process of atherosclerosis. Atherosclerosis is thickening of arterial wall which bring anout the narrowing of arterial lumen-(menurunnyaa) elasticity of vessel and (menurunkan) blood circulation so its cause damage and dysfunction of heart muscle, brain and lung. Endothelial demage can cause many thing there are hiperlipidemia, hypertension, smoking, diabetes mellitus, hyperhomocystemia, age, genetic risk factor. When the endothelian has demage there are 3 happen its increase of lipid permeability, monoci