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Kinetics of Single and Multple idoses of drugs

Kinetics of Single and Multple idoses of drugs

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Published by Sunil
Kinetics of Single and Multple idoses of drugs
Kinetics of Single and Multple idoses of drugs

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Categories:Types, School Work
Published by: Sunil on Jul 20, 2013
Copyright:Attribution Non-commercial

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11/11/2013

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KINETICS FOLLOWINGSINGLE AND MULTIPLEDOSAGE OF DRUG
 
 
The speed of onset, intensity, and duration of a pharmacological effect depend on theconcentration of drugat itssite(s) of action
As it is difficult to collect tissue samples, the time course of drug concentration at its site of action is approximated bymeasuring drug concentration in plasma, which can be measuredwith accuracy
The plasma drug concentration-time curve is obtained bymeasuring the concentration of drug in plasma samples taken atvarious intervals of time after administration of a dosage form and plotting the
concentration of drug in plasma (Y-axis) versus thecorresponding time at which the plasma samples werecollected (X-axis)
Plasma Drug Concentration-Time Profile
 
If a drug is administered by
oral or extravascular(IM, SC, IP, etc.) route, it slowly enters the systemiccirculation and plasma drug concentration graduallyrises to a
maximum (peak level)
As the drug is being absorbed into blood, it isdistributed to body tissues and may also simultaneously being eliminated
The ascending portion of curve to the left of peak represents the absorption phase because in this phase rateof absorption is greater than rate of distribution andelimination

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