Welcome to Scribd, the world's digital library. Read, publish, and share books and documents. See more
Download
Standard view
Full view
of .
Save to My Library
Look up keyword or section
Like this
1Activity

Table Of Contents

0 of .
Results for:
No results containing your search query
P. 1
Reduction

Reduction

Ratings: (0)|Views: 16 |Likes:
Published by Sunil
Reduction
Reduction

More info:

Categories:Types, School Work
Published by: Sunil on Jul 20, 2013
Copyright:Attribution Non-commercial

Availability:

Read on Scribd mobile: iPhone, iPad and Android.
download as PPT, PDF, TXT or read online from Scribd
See more
See less

01/01/2014

pdf

text

original

 
PHASE I:REDUCTION OF XENOBIOTICS
 
 
Certain metals (e.g., pentavalent arsenic) andxenobiotics containing an
aldehyde, ketone, alkene,disulfide, sulfoxide, quinone,
Noxide,
hydroxamic acid,amidoxime, isoxazole, isothiazole, azo, or nitro group
are often reduced in vivo
Although it is sometimes difficult to ascertain whether
the reaction proceeds
enzymatically ornonenzymatically by interaction with reducing agents(such as the
reduced forms of glutathione, FAD, FMN,and NAD[P]).
 
Functional groups can be either reduced or oxidized.
Eg:1
.
aldehydes
(R
 –
CHO-reduced to
an alcohol
(R
 –
CH2OH) or
oxidizedto a carboxylic acid (R
 –
COOH)2. sulfoxides
(R1
 –
SO
 –
R2) can be reduced to
a sulfide (R1
 –
S
 –
R2
) or
oxidized to a sulfone
(R1
 –
SO2
 –
R2).
Enzymes,
alcohol dehydrogenase, aldehyde oxidase, andcytochrome P450, can catalyze both reductive and oxidativereactions
depending on the substrate or conditions.
In the case of halogenated hydrocarbons, such as halothane,dehalogenation can proceed by an oxidative or reductive pathway,both of which are catalyzed by the same enzyme (namely,cytochrome P450).
In azo-reduction, nitro-reduction, and the reduction of certainalkenes, the reaction is largely catalyzed by intestinal microflora

You're Reading a Free Preview

Download
/*********** DO NOT ALTER ANYTHING BELOW THIS LINE ! ************/ var s_code=s.t();if(s_code)document.write(s_code)//-->