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Acknowledgments We thank our laboratory members for critical reading of the manuscript.

We are thankful toHelmut Jungwirth and Christoph Schuller for helping with graphics and artwork. Research in our laboratory is supported by grants from the Christian Doppler Research Society, the EraNet Pathogenomics project FunPath (FWF-I0125), the Austrian Science Foundation (FWF-SFB35-04), the FP6 Marie Curie Training Networks CanTrain (MRTN-CT-2004-512481) and Flippases (MRTN-CT2004-5330), the FP6 EURESFUN project (STREP-2004-CT-PL518199), the Austrian GenAU research program (SysMo-MOSES), the Herzfelder Family Foundation, and the Vienna Biocenter PhD program.

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