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eicosanoids

eicosanoids

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Published by Bushra Vakil
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Published by: Bushra Vakil on Jul 27, 2013
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07/27/2013

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EICOSANOIDS
(prostaglandins,thromboxanes, leukotrienes)
 
Eicosanoids
Major classes of eicosanoids.
Precursors of eicosanoids.
Major pathways of eicosanoid synthesis(cyclooxygenase and lipoxygenase).
Important functions of eicosanoids.
Important inhibitors of eicosanoidsynthesis
 
Eicosaniods
Derived from 20-crabon polyunsaturated fattyacids
Paracrine or autocrine messengers molecules
Short half-lives (10 secs
 –
5 mins) so that functionsare usually limited to actions on nearby cells.
Bind to specific cell surface G-protein coupledreceptors, and generally increase cAMP levels.May also bind to nuclear receptors and alter genetranscription.
Wide variety of functions

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