actin

actin

troponin

tropomyosin

actin

troponin

tropomyosin

actin

troponin

myosin binding site tropomyosin

actin

troponin

Ca2+

Ca2+

Ca2+

Ca2+

Ca2+

Ca2+

Ca2+

Ca2+

Calcium ions are released from the sarcolemma after stimulation from the T system

Ca2+

Ca2+

Ca2+ Ca2+

Ca2+

Ca2+

Ca2+ Ca2+

the calcium ions bind to the troponin and changes its shape

Ca2+

Ca2+

Ca2+ Ca2+

the calcium ions bind to the troponin and changes its shape

Ca2+

Ca2+

Ca2+ Ca2+

Ca2+

Ca2+

Ca2+ Ca2+

Ca2+

Ca2+

Ca2+ Ca2+

the troponin displaces the tropomyosin and exposes the myosin binding sites

Ca2+

Ca2+

Ca2+ Ca2+

Ca2+

Ca2+

Ca2+ Ca2+

Ca2+

Ca2+

Ca2+ Ca2+

the bulbous heads of the myosin attach to the binding sites on the actin filaments

Ca2+

Ca2+

Ca2+ Ca2+

Ca2+

Ca2+ Ca2+

Ca2+

Ca2+ Ca2+

the myosin heads change position to achieve a lower energy state and slide the actin filaments past the stationary myosin

Ca2+

Ca2+ Ca2+

Pi Pi Pi A

Pi Pi Pi A

Pi Pi Pi A

Pi Pi Pi A

Pi Pi Pi Ca A 2+

Ca2+

Pi Pi Pi A

Ca2+

Pi Pi Pi A

Pi Pi Pi Ca A 2+

Ca2+

Pi Pi Pi A

Ca2+

ATP binds to the bulbous heads and causes it to become detached

Pi Pi Pi A Pi Pi Pi A

Pi Pi Pi A

Ca2+

Ca2+ Ca2+

ATP binds to the bulbous heads and causes it to become detached

Pi Pi Pi A Pi Pi Pi A Pi Pi Pi A

Ca2+

Ca2+ Ca2+

hydrolysis of ATP provides the energy to re-cock the heads

Pi Pi Pi A Pi Pi Pi A Pi Pi Pi A

Ca2+

Ca2+ Ca2+

hydrolysis of ATP provides the energy to re-cock the heads

Pi Pi Pi A Pi Pi Pi A Pi Pi Pi A

Ca2+

Ca2+

Ca2+

Pi Pi Pi A Pi Pi Pi A Pi Pi Pi A

Ca2+

Ca2+

Ca2+

calcium ions are re-absorbed back into the T system

Pi Pi Pi A Pi Pi Pi A Pi Pi Pi A

calcium ions are re-absorbed back into the T system

Pi Pi Pi A Pi Pi Pi A Pi Pi Pi A

the troponin reverts to its normal shape and the tropomyosin move back to block the myosin binding sites

Pi Pi Pi A Pi Pi Pi A Pi Pi Pi A

the troponin reverts to its normal shape and the tropomyosin move back to block the myosin binding sites

Pi Pi Pi A Pi Pi Pi A Pi Pi Pi A

the troponin reverts to its normal shape and the tropomyosin move back to block the myosin binding sites

Pi Pi Pi A Pi Pi Pi A Pi Pi Pi A

phosphocreatine regenerates ATP

Pi Pi Pi Pi A

Pi Pi A Pi Pi Pi A

phosphocreatine regenerates ATP

Pi Pi Pi A Pi Pi Pi A

Pi Pi Pi A

phosphocreatine regenerates ATP