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Hormone Thyroid T3, T4 Target Nuclear Receptors of: Most

Hormone Thyroid T3, T4 Target Nuclear Receptors of: Most

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Published by mcwnotes

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Published by: mcwnotes on May 21, 2009
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02/02/2013

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Hormone Target Action Regulation Clinical
Thyroid
T3, T4Nuclear Receptors of:Most tissues
O
2
consumption, heat (d/t
metabolism)Bone MarrowErythropoeisisGI tract
motilityBone
bone turnover CardiacAlters myosin isoenzymesTSH stimsHypothyroidism-Children-cretinism-Adults-myxedema- fatigue, constipation, puffy face/hands, weight gain, m.weakness (accumulation of GAGs)Hyperthyroidism – Grave’s Dz goiter,ophthalmopathy, palpitations,
weight,heat intolerance
Parathyroid
PTHBone
bone resorption (
Ca
+2
)Kidney
Ca
+2
reabsorption, PO
4-3
secretionIntestine
Ca
+2
absorption via Vit. DHypo-low blood Ca
+2
can cause tetanyHyper-hypercalcemia andhypophosphatemia
Adrenal Cortex
 Zona Glomerulosa-
MineralocorticoidsMaintain plasma volume via Na
+
retention, K 
+
excretionRenin-AngiotensinsystemHyper-1
°
/2
°
Aldosteronism-HTN d/thypernatremia & ECF expansion; m.weakness, fatigue d/t hyperkalemiaHypo of 
aldosterone
-1
°
AdrenocorticalInsufficiency (Addison’s Dz)-dehydration,HTN, hyponatremia (Na
+
wasting),hyperkalemia (K 
+
retention)
 Zona Fasciculata-
Glucocorticoids (Cortisol,Hydrocortisone)Gonadocorticoids(androgens)
gluconeogenesis, lipolysis, proteincatabolism,
glycolysis, insulin use,
immune, inflammatory responseCRF-ACTH systemHyper-Cushings Dz-truncal obesity, moonfacies, HTN, gonadal dysfxnHypo of 
cortisol 
-1
°
AdrenocorticalInsufficiency (Addison’s Dz)- fatigue,hyperpigmentation, GI abnormalitiesGlucocorticoids can impair immune fxn
 Zona Reticularis-
Glucocorticoids, weak androgens (DHEA)See aboveDHEA precursor for T (negligible in males)CRF-ACTH systemCAH-
response to ACTH
 
androgens – female pseudohermaphroditism - AdrenalAndrogen HyperS – hirsutism,oligomenorrhea, acne, virilization of females
Adrenal Medulla
Catecholamines (Norepi,Epi)Fight-or-flight response (
HR, CO, BP, Resp.rate, bronchiole dilation, vasoconstrict skin/gut,vasodilate heart, skeletal m.)ACh
exocytosis of secretory granulesTumor (pheochromocytoma) may causesudden onset HTN, headache, sweating, palpitations, tachycardia

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