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Giant Cell Tumor or Osteoclastoma

Giant Cell Tumor or Osteoclastoma

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Published by Aditya Pathak

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Published by: Aditya Pathak on May 22, 2009
Copyright:Attribution Non-commercial


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Giant cell tumor Or Osteoclastoma
Its so named because it contains multinucleatedosteoclast like giant cells.It is benign but locally aggressive neoplasmoccuring usually in 20 to 40 yrs age gr.Clinically located at the ends of long bonearising from epiphysis close to articular cartilage.Commonest site is knee(distal femur or proximal tibia) ,lower end of radius upper end of fibula
Gross appearance
The tumor is eccentrically located at epiphysealend of long bone.It is large well circumscribed reddish brown andfrequently undergoes cystic degeneration.The mass remains covered by thin shell of subperiosteal bone.The cut surface is haemorrhagic necrotichoneycombed due to cystic degenrn.
Microscopic feature
The hallmark of GCT is presence of large no of multinucleated giant cells which are scatteredthroughout the stromal mononuclear cells.These stromal cells are uniform plump spindleshaped or round to oval cells with numerousmitotic figures. These are real tumor cellsbelonging to mononuclaer family .Stroma has scanty collagen content ,richvascularity and abundant macrophages.Somewhere areas of haemorrhage can be seen.Giant cells contain as many as hundred benignnuclei and are similar to osteoclasts

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