Disorder Labs Cause Signs/Symptoms Other
Hyperprolactinema
↓
FSH, LHPituitary tumorBilateral milky discharge,amenorrhea, headachesAdrenal Insufficiency1
°
(Addison’s)
↑
ACTHAutoimmune destruction of adrenalsWeakness, fatigue, anorexia,weight loss, hyperpigmentation,hypotension, GI problems, saltcravingFatal if not txTest w/ ACTH stim test – AI= subnormal cortisolresponse2
°
(Hypopituitarism)
↓
ACTHAdrenals atrophyCongenital AdrenalHyperplasia(Adrenogential Syndrome)
↑
Androgens21-
β
-Hydroxylase deficiency mostcommon, adrenal tumor -
↑
amt 17-OH-progesterone and pregnenolone
→
converted to androgensVirilization of female fetusSame effects in male + rapidgenital devo if prepubertalMost common cause of ambiguous genitalia infemale babiesMasked in adult male bytestosterone from testesCushing’s Syndrome
↑
glucocorticoids (cortisol)Endogenous (excess from adrenals)Exogenous (rx)Moon facies, red cheeks,truncal obesity, HTN, thin skin,striae, m. atrophy (
↑
catabolismfor gluconeogenesis), hirsutismTest w/ salivary cortisol at bedtime d/t circadianrhythmicityACTH Dependent
↑
ACTHPituitary tumor Ectopic tumor SameCushing’s DzDifferentiate – test bloodin petrosal sinus (
↑
= pituitary,
↓
=ectopic)ACTH Independent
↓
ACTHAdrenal tumor -
↑
cortisol w/o ACTHSameGH Excess
↑
IGF-1GH secreting pituitary tumorTall statureLarge forehead, tongue, nose, jaw, hands, etcPre-puberty-gigantismPost-puberty-acromegalyGH DeficiencyStimulation testHypopituitarismShort stature, thinHypothyroidismtT4TBGfT4TSHCretinism in children1
°
(Hashimoto’sThyroiditis)
↓
N
↓ ↑
Autoimmune antithyroid AbMyxedema -
↑
GAGs pull H2Ointo skin2
° ↓
N
↓ ↓
/NHypopituitarismHyperthyroidism1
°
(Grave’s Dz)
↑
N
↑ ↓
Autoimmune stim TSH-R via
↑
TSIPemberton sign2
°
↑
N
↑ ↑
TSH secreting tumorVery rare
of 00
Disorder Hyperprolactinema Adrenal Insufficiency 1° (Addison’s) ↓ FSH, LH
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| Category: | Uncategorized. |
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| Upload Date: | 05/28/2009 |
| Copyright: | Attribution Non-commercial |
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