•Acute UTI

•Respiratory tract infections

•Orofacial infections???
 1. Pregnancy

Birth defects
2. Children

Cartilage damage
1.Diarrhoea
2. Rashes
 P r o d r u g
u r b i n te s t i n al
es n o t d i s t
1. Do
ecol og y [ F l o r a ]
u e p e n e t r a t i o n
2. Bet t e r t i ss
Bacteria→ß-Lactamases→Inactivate
Amoxicillin
Reestablishes
activity of
Inhibits Amoxicillin

Clavulanic
acid
referred drug in:
typical[Mycoplasma] pneumonia

Adverse effect:
Epigastric pain
 It is a component of triple drug
regimen
against H.Pylori found in peptic ulcers

Gastrointestinal:
Nausea, vomiting,Metallic taste
1.Hepatotoxicity
2.Hyperuricemia→
Gout
urotoxicity-Peripheral neuri
Pyridoxine
100mg/day
Optic neuritis-Loss of
visual acuity,
Loss of Colour
Difficult vision,
to detect in
field defects
children
 . Leprosy
2.H.Influenza/Meningococcal meningitis-
Prophylaxis
 . Herpes simplex
2.Herpes zoster
3.Chicken pox
Use:
In the tt of HIV infected pts [In
combination with other ARV drug]

ADE:Anemia and neutropenia